Test Details
Methodology
DNA probe; in situ hybridization
Result Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Determine HPV type; confirm HPV infection; resolve cases with equivocal histopathology
Limitations
More than 20 distinct HPV types have been isolated from the anogenital mucosa. This assay can detect the presence of six specific viral types: HPV 6, 11, 16, 18, 31, and 33.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Specimen Requirements
Specimen
Tissue
Volume
One formalin-fixed, paraffin embedded (FFPE) tissue block or eight unstained positively charged slides sectioned from FFPE tissue block at 4 to 5 microns
Minimum Volume
Five unstained tissue slides
Container
Paraffin block transport pouch or slide container
Collection Instructions
Tissue biopsy should be fixed in 10% neutral buffered formalin for no more than 72 hours. Embed in paraffin.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Insufficient tissue; inappropriate tissue source; incorrect specimen type
References
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 503500 | HPV ISH Low/High Risk Subtypes | 503502 | HPV 6/11 | 18480-4 | ||
| 503500 | HPV ISH Low/High Risk Subtypes | 503586 | HPV 16/18 | 18478-8 | ||
| 503500 | HPV ISH Low/High Risk Subtypes | 503587 | HPV 31/33 | 81439-2 | ||
| 503500 | HPV ISH Low/High Risk Subtypes | 503596 | Comment: | 77202-0 | ||
| 503500 | HPV ISH Low/High Risk Subtypes | 503588 | Director Review | 72486-4 | ||
| Order Code | 503500 | |||||
| Order Code Name | HPV ISH Low/High Risk Subtypes | |||||
| Order Loinc | ||||||
| Result Code | 503502 | |||||
| Result Code Name | HPV 6/11 | |||||
| UofM | ||||||
| Result LOINC | 18480-4 | |||||
| Order Code | 503500 | |||||
| Order Code Name | HPV ISH Low/High Risk Subtypes | |||||
| Order Loinc | ||||||
| Result Code | 503586 | |||||
| Result Code Name | HPV 16/18 | |||||
| UofM | ||||||
| Result LOINC | 18478-8 | |||||
| Order Code | 503500 | |||||
| Order Code Name | HPV ISH Low/High Risk Subtypes | |||||
| Order Loinc | ||||||
| Result Code | 503587 | |||||
| Result Code Name | HPV 31/33 | |||||
| UofM | ||||||
| Result LOINC | 81439-2 | |||||
| Order Code | 503500 | |||||
| Order Code Name | HPV ISH Low/High Risk Subtypes | |||||
| Order Loinc | ||||||
| Result Code | 503596 | |||||
| Result Code Name | Comment: | |||||
| UofM | ||||||
| Result LOINC | 77202-0 | |||||
| Order Code | 503500 | |||||
| Order Code Name | HPV ISH Low/High Risk Subtypes | |||||
| Order Loinc | ||||||
| Result Code | 503588 | |||||
| Result Code Name | Director Review | |||||
| UofM | ||||||
| Result LOINC | 72486-4 |