Venous Thrombosis (Hypercoagulability) Profile for Patients on Vitamin K Antagonist (VKA) Therapy (Esoterix)

TEST: 501768
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CPT: 81240; 83090; 85230; 85240; 85300; 85302; 85305; 85307; 85598; 85613(x2); 85730; 85732(x2); 86146(x3); 86147(x2)
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Test Includes

Activated partial thromboplastin time (aPTT); anticardiolipin antibodies IgG, IgM; antithrombin activity; β2-glycoprotein I, IgA, IgG, IgM; dilute Russell's viper venom time (dRVVT) confirm seconds; dilute Russell's viper venom time (dRVVT) ratio; dilute Russell's viper venom time (dRVVT) screen seconds; factor II gene mutation; factor VII antigen; factor VIII activity; hexagonal phospholipid neutralization; homocysteine; protein C antigen; protein C antigen and factor VII antigen ratio; protein C resistance with factor V deficiency; protein S antigen and factor VII antigen ratio; protein S antigen, total

Special Instructions

Informed consent is required for New York patients. Will reflex to Factor V Leiden Gene Mutation if APCR is abnormal. If abnormal, aPTT will reflex to Immediate aPTT Mixing Studies. If reflex testing is performed, concomitant CPT codes/charges will apply.

Expected Turnaround Time

5 - 10 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Procedures for Hemostasis and Thrombosis: A Clinical Test Compendium

    Specimen Requirements

    Specimen

    Serum, plasma, and whole blood

    Volume

    6 mL (2 mL in each of three tubes) platelet-poor citrated plasma, frozen, 5 mL whole blood, and 2 mL serum, frozen

    Container

    Gel-barrier tube or red-top tube, lavender-top (EDTA) tube, or yellow-top (ACD) tube, and blue-top (sodium citrate) tube

    Collection

    Plasma must be separated from cells within 45 minutes of venipuncture and must be centrifuged a second time before being placed in plastic transport tubes. Freeze within two hours and keep frozen until testing is performed. Allow red-top tube to clot. Centrifuge and remove serum from cells within one hour. Send serum in plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

    Storage Instructions

    Freeze serum and plasma. Maintain whole blood at room temperature; stable for seven days.

    Causes for Rejection

    Noncitrated plasma; gross hemolysis; fibrin clot; clotted samples if adequate DNA not obtained

    Test Details

    Limitations

    This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.

    Methodology

    See individual tests.

    LOINC® Map

    Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
    501768 Venous Thromb. Patients on VKA 501701 Homocysteine umol/L 13965-9
    501768 Venous Thromb. Patients on VKA 500666 Factor VIII Activity % 3209-4
    501768 Venous Thromb. Patients on VKA 500573 Antithrombin Activity, Plasma % 27811-9
    501768 Venous Thromb. Patients on VKA 500608 Protein C Antigen % 27820-0
    501768 Venous Thromb. Patients on VKA 500531 Protein S Antigen, Total % 27823-4
    501768 Venous Thromb. Patients on VKA 500532 Factor VII Antigen** % 49870-9
    501768 Venous Thromb. Patients on VKA 500536 Protein C Ag/FVII Ag Ratio** ratio 27438-1
    501768 Venous Thromb. Patients on VKA 500533 Protein S Ag/FVII Ag Ratio** ratio 18345-9
    501768 Venous Thromb. Patients on VKA 501172 Act. Prt C Resist w/FV Defic. ratio 13590-5
    501768 Venous Thromb. Patients on VKA 500513 APTT sec 14979-9
    501768 Venous Thromb. Patients on VKA 500363 APTT 1:1 NP sec 5946-9
    501768 Venous Thromb. Patients on VKA 500364 APTT 1:1 Saline Sec 43734-3
    501768 Venous Thromb. Patients on VKA 502038 LAC Interpretation 77202-0
    501768 Venous Thromb. Patients on VKA 501549 DRVVT Screen Seconds sec 6303-2
    501768 Venous Thromb. Patients on VKA 501548 DRVVT Confirm Seconds sec 57838-5
    501768 Venous Thromb. Patients on VKA 500585 DRVVT Ratio ratio 50410-0
    501768 Venous Thromb. Patients on VKA 500569 Hexagonal Phospholipid Neutral sec 3282-1
    501768 Venous Thromb. Patients on VKA 500575 Anticardiolipin Ab, IgG GPL 3181-5
    501768 Venous Thromb. Patients on VKA 500571 Anticardiolipin Ab, IgM MPL 3182-3
    501768 Venous Thromb. Patients on VKA 500589 Beta-2 Glycoprotein I, IgG SGU 16135-6
    501768 Venous Thromb. Patients on VKA 500593 Beta-2 Glycoprotein I, IgM SMU 16136-4
    501768 Venous Thromb. Patients on VKA 500591 Beta-2 Glycoprotein I, IgA SAU 21108-6
    501768 Venous Thromb. Patients on VKA 500583 Factor II Gene Mutation Result 24476-4
    501768 Venous Thromb. Patients on VKA 500624 Interpretation: 51968-6
    501768 Venous Thromb. Patients on VKA 500625 Methodology: 49549-9
    501768 Venous Thromb. Patients on VKA 500626 Comments: 77202-0

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    The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf