Test Details
Methodology
See individual tests.
Result Turnaround Time
5 - 10 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
Activated partial thromboplastin time (aPTT); anticardiolipin antibodies IgG, IgM; antithrombin activity; β2-glycoprotein I, IgA, IgG, IgM; dilute Russell's viper venom time (dRVVT) confirm seconds; dilute Russell's viper venom time (dRVVT) ratio; dilute Russell's viper venom time (dRVVT) screen seconds; factor II gene mutation; factor VII antigen; factor VIII activity; hexagonal phospholipid neutralization; homocysteine; protein C antigen; protein C antigen and factor VII antigen ratio; protein C resistance with factor V deficiency; protein S antigen and factor VII antigen ratio; protein S antigen, total
Special Instructions
Informed consent is required for New York patients. Will reflex to Factor V Leiden Gene Mutation if APCR is abnormal. If abnormal, aPTT will reflex to Immediate aPTT Mixing Studies. If reflex testing is performed, concomitant CPT codes/charges will apply.
Limitations
This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.
Specimen Requirements
Specimen
Serum, plasma, and whole blood
Volume
6 mL (2 mL in each of three tubes) platelet-poor citrated plasma, frozen, 5 mL whole blood, and 2 mL serum, frozen
Container
Gel-barrier tube or red-top tube, lavender-top (EDTA) tube, or yellow-top (ACD) tube, and blue-top (sodium citrate) tube
Collection Instructions
Plasma must be separated from cells within 45 minutes of venipuncture and must be centrifuged a second time before being placed in plastic transport tubes. Freeze within two hours and keep frozen until testing is performed. Allow red-top tube to clot. Centrifuge and remove serum from cells within one hour. Send serum in plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Freeze serum and plasma. Maintain whole blood at room temperature; stable for seven days.
Causes for Rejection
Noncitrated plasma; gross hemolysis; fibrin clot; clotted samples if adequate DNA not obtained
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 501768 | Venous Thromb. Patients on VKA | 501701 | Homocysteine | umol/L | 13965-9 | |
| 501768 | Venous Thromb. Patients on VKA | 500666 | Factor VIII Activity | % | 3209-4 | |
| 501768 | Venous Thromb. Patients on VKA | 500573 | Antithrombin Activity, Plasma | % | 27811-9 | |
| 501768 | Venous Thromb. Patients on VKA | 500608 | Protein C Antigen | % | 27820-0 | |
| 501768 | Venous Thromb. Patients on VKA | 500531 | Protein S Antigen, Total | % | 27823-4 | |
| 501768 | Venous Thromb. Patients on VKA | 500532 | Factor VII Antigen** | % | 49870-9 | |
| 501768 | Venous Thromb. Patients on VKA | 500536 | Protein C Ag/FVII Ag Ratio** | ratio | 27438-1 | |
| 501768 | Venous Thromb. Patients on VKA | 500533 | Protein S Ag/FVII Ag Ratio** | ratio | 18345-9 | |
| 501768 | Venous Thromb. Patients on VKA | 501172 | Act. Prt C Resist w/FV Defic. | ratio | 13590-5 | |
| 501768 | Venous Thromb. Patients on VKA | 500513 | APTT | sec | 14979-9 | |
| 501768 | Venous Thromb. Patients on VKA | 500363 | APTT 1:1 NP | sec | 5946-9 | |
| 501768 | Venous Thromb. Patients on VKA | 500364 | APTT 1:1 Saline | Sec | 43734-3 | |
| 501768 | Venous Thromb. Patients on VKA | 502038 | LAC Interpretation | 77202-0 | ||
| 501768 | Venous Thromb. Patients on VKA | 501549 | DRVVT Screen Seconds | sec | 6303-2 | |
| 501768 | Venous Thromb. Patients on VKA | 501548 | DRVVT Confirm Seconds | sec | 57838-5 | |
| 501768 | Venous Thromb. Patients on VKA | 500585 | DRVVT Ratio | ratio | 50410-0 | |
| 501768 | Venous Thromb. Patients on VKA | 500569 | Hexagonal Phospholipid Neutral | sec | 3282-1 | |
| 501768 | Venous Thromb. Patients on VKA | 500575 | Anticardiolipin Ab, IgG | GPL | 3181-5 | |
| 501768 | Venous Thromb. Patients on VKA | 500571 | Anticardiolipin Ab, IgM | MPL | 3182-3 | |
| 501768 | Venous Thromb. Patients on VKA | 500589 | Beta-2 Glycoprotein I, IgG | SGU | 16135-6 | |
| 501768 | Venous Thromb. Patients on VKA | 500593 | Beta-2 Glycoprotein I, IgM | SMU | 16136-4 | |
| 501768 | Venous Thromb. Patients on VKA | 500591 | Beta-2 Glycoprotein I, IgA | SAU | 21108-6 | |
| 501768 | Venous Thromb. Patients on VKA | 500583 | Factor II Gene Mutation Result | 24476-4 | ||
| 501768 | Venous Thromb. Patients on VKA | 500624 | Interpretation: | 51968-6 | ||
| 501768 | Venous Thromb. Patients on VKA | 500625 | Methodology: | 49549-9 | ||
| 501768 | Venous Thromb. Patients on VKA | 500626 | Comments: | 77202-0 | ||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 501701 | |||||
| Result Code Name | Homocysteine | |||||
| UofM | umol/L | |||||
| Result LOINC | 13965-9 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500666 | |||||
| Result Code Name | Factor VIII Activity | |||||
| UofM | % | |||||
| Result LOINC | 3209-4 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500573 | |||||
| Result Code Name | Antithrombin Activity, Plasma | |||||
| UofM | % | |||||
| Result LOINC | 27811-9 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500608 | |||||
| Result Code Name | Protein C Antigen | |||||
| UofM | % | |||||
| Result LOINC | 27820-0 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500531 | |||||
| Result Code Name | Protein S Antigen, Total | |||||
| UofM | % | |||||
| Result LOINC | 27823-4 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500532 | |||||
| Result Code Name | Factor VII Antigen** | |||||
| UofM | % | |||||
| Result LOINC | 49870-9 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500536 | |||||
| Result Code Name | Protein C Ag/FVII Ag Ratio** | |||||
| UofM | ratio | |||||
| Result LOINC | 27438-1 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500533 | |||||
| Result Code Name | Protein S Ag/FVII Ag Ratio** | |||||
| UofM | ratio | |||||
| Result LOINC | 18345-9 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 501172 | |||||
| Result Code Name | Act. Prt C Resist w/FV Defic. | |||||
| UofM | ratio | |||||
| Result LOINC | 13590-5 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500513 | |||||
| Result Code Name | APTT | |||||
| UofM | sec | |||||
| Result LOINC | 14979-9 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500363 | |||||
| Result Code Name | APTT 1:1 NP | |||||
| UofM | sec | |||||
| Result LOINC | 5946-9 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500364 | |||||
| Result Code Name | APTT 1:1 Saline | |||||
| UofM | Sec | |||||
| Result LOINC | 43734-3 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 502038 | |||||
| Result Code Name | LAC Interpretation | |||||
| UofM | ||||||
| Result LOINC | 77202-0 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 501549 | |||||
| Result Code Name | DRVVT Screen Seconds | |||||
| UofM | sec | |||||
| Result LOINC | 6303-2 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 501548 | |||||
| Result Code Name | DRVVT Confirm Seconds | |||||
| UofM | sec | |||||
| Result LOINC | 57838-5 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500585 | |||||
| Result Code Name | DRVVT Ratio | |||||
| UofM | ratio | |||||
| Result LOINC | 50410-0 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500569 | |||||
| Result Code Name | Hexagonal Phospholipid Neutral | |||||
| UofM | sec | |||||
| Result LOINC | 3282-1 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500575 | |||||
| Result Code Name | Anticardiolipin Ab, IgG | |||||
| UofM | GPL | |||||
| Result LOINC | 3181-5 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500571 | |||||
| Result Code Name | Anticardiolipin Ab, IgM | |||||
| UofM | MPL | |||||
| Result LOINC | 3182-3 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500589 | |||||
| Result Code Name | Beta-2 Glycoprotein I, IgG | |||||
| UofM | SGU | |||||
| Result LOINC | 16135-6 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500593 | |||||
| Result Code Name | Beta-2 Glycoprotein I, IgM | |||||
| UofM | SMU | |||||
| Result LOINC | 16136-4 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500591 | |||||
| Result Code Name | Beta-2 Glycoprotein I, IgA | |||||
| UofM | SAU | |||||
| Result LOINC | 21108-6 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500583 | |||||
| Result Code Name | Factor II Gene Mutation Result | |||||
| UofM | ||||||
| Result LOINC | 24476-4 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500624 | |||||
| Result Code Name | Interpretation: | |||||
| UofM | ||||||
| Result LOINC | 51968-6 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500625 | |||||
| Result Code Name | Methodology: | |||||
| UofM | ||||||
| Result LOINC | 49549-9 | |||||
| Order Code | 501768 | |||||
| Order Code Name | Venous Thromb. Patients on VKA | |||||
| Order Loinc | ||||||
| Result Code | 500626 | |||||
| Result Code Name | Comments: | |||||
| UofM | ||||||
| Result LOINC | 77202-0 |