Thyroglobulin, Comprehensive (With Anti-Tg Screen and Reflex to RIA) (Endocrine Sciences)

TEST: 500540
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CPT: 84432; 86800
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Synonyms

  • Extended-storage Comprehensive Thyroglobulin (With Anti-Tg Screen and Reflex to RIA)

Expected Turnaround Time

4 - 10 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

LABupdate: Enhanced Sensitivity for Thyroglobulin and Anti-thyroglobulin Testing

Thyroid Testing: Assessing Thyroid Disease in Your Patients

Specimen Requirements

Specimen

Serum

Volume

5 mL

Minimum Volume

1.5 mL (Note: This volume does not allow for repeat testing.)

Container

Gel-barrier tube or red-top tube

Collection

Transfer specimen to a plastic transport tube before freezing. Serum must be separated from cells within one hour of venipuncture. Submit serum in a plastic transport tube.

Storage Instructions

Freeze. Stable at room temperature for three days or refrigerated for 14 days. Stable when frozen for 3.79 years. Freeze/thaw cycles: stable x2.

Causes for Rejection

Plasma specimen received; gross hemolysis

Test Details

Use

Comprehensive thyroglobulin can be used to monitor recurrence of thyroid cancer. All specimens are tested for the presence of antithyroglobulin autoantibodies (anti-Tg). Specimens negative for the presence of anti-Tg are reflexed to thyroglobulin testing by ICMA, and specimens positive for the presence of anti-Tg are reflexed to thyroglobulin testing by RIA.

Specimens submitted for comprehensive thyroglobulin testing are stored frozen for one year to allow for future testing.

Methodology

Immunochemiluminometric (ICMA) or double antibody radioimmunoassay (RIA) when anti-Tg autoantibodies are present

References

Cooper DS, Doherty GM, Haugen BR, The American Thyroid Association Guideline Taskforce, et al. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2006; 16(2):109-142. 16420177
Mazzaferri EL, Robbins RJ, Spencer CA, et al. A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab. 2003; 88(4):1433-1441. 12679418
National Academy for Clinical Biochemistry. Laboratory Support for the Diagnosis of Thyroid Disease. Vol 13. 2002:48-49.
Spencer CA, Bergoglio LM, Kazarosyan M, et al. Clinical impact of thyroglobulin (Tg) and Tg autoantibody method differences on the management of patients with differentiated thyroid carcinomas. J Clin Endocrinol Metab. 2005; 90(10):5566-5575. 15985472

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
500540 Comprehensive Thyroglobulin 57780-9 500556 Anti-Thyroglobulin Antibodies IU/mL 8098-6
500540 Comprehensive Thyroglobulin 57780-9 503191 Thyroglobulin (ICMA) ng/mL 3013-0
500540 Comprehensive Thyroglobulin 57780-9 500002 Thyroglobulin (TG-RIA) ng/mL 3013-0

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