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1st Trimester Preeclampsia Screen

Test Number 486230
Test number copied
CPT

81599
Synonyms

Preeclampsia, First Trimester

Test Details

Methodology

Fluoroimmunometric assay

Result Turnaround Time

2 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Use

This test is a screening test for the development of preeclampsia prior to 34 weeks of pregnancy.

Special Instructions

For test inquiries, call CMBP genetic services at 800-345-4363. The following information must also be provided: patient's weight and height, patient's date of birth, four blood pressure measurements (two from each arm) or mean arterial pressure (MAP), uterine artery pulsatility index (UtAPI is optional) and number of fetuses. Also indicate relevant patient history (i.e., prior history of preeclampsia, diabetes, smoking status). Serum testing is provided from 11.0 to 14.0 weeks gestation. The UtAPI measurement is optional but desired and if provided must be performed by a sonographer credentialed by the Fetal Medicine Foundation or other equivalent entity. The sonographer's credential/certification number must be provided.

 

 

 

 

Limitations

This is a screening test for preeclampsia to classify patients as low or high risk to develop preeclampsia later in pregnancy. 

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.

References

Tan MY, Wright D, Syngelaki A, et al. Comparison of diagnostic accuracy of early screening for pre-eclampsia by NICE guidelines and a method combining maternal factors and biomarkers: results of SPREE. Ultrasound Obstet Gynecol. 2018 Jun;51(6):743-750. PubMed 29536574
 

Specimen Requirements

Specimen

Serum

Volume

3 mL

Minimum Volume

1 mL

Container

Gel-barrier tube

Collection Instructions

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Pour off serum into plastic transport tube before freezing. Transport tube to testing laboratory frozen (preferred) or refrigerated. If transfer to a transport tube is not possible, transport serum separator tube refrigerated to testing laboratory. Frozen serum separator tubes are not acceptable.

Stability Requirements

TemperaturePeriod
Room temperatureUnstable
Refrigerated10 days
Frozen10 days
Freeze/thaw cyclesStable x3

Storage Instructions

Frozen (preferred) or refrigerated

Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type; received at room temperature

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
486230 Pre-E Screen 1st Trimester 486409 Results 49086-2
486230 Pre-E Screen 1st Trimester 486410 Test Results N/A
486230 Pre-E Screen 1st Trimester 486413 Preeclampsia Interpetation N/A
486230 Pre-E Screen 1st Trimester 486418 Preeclampsia Scr Risk lt 34wk N/A
486230 Pre-E Screen 1st Trimester 486419 Preeclampsia Prescreen Risk N/A
486230 Pre-E Screen 1st Trimester 486420 Comments N/A
486230 Pre-E Screen 1st Trimester 486427 Mean Arterial Pressure Value mmHg N/A
486230 Pre-E Screen 1st Trimester 486428 Mean Arterial Pressure MoM N/A
486230 Pre-E Screen 1st Trimester 486429 UtAPI Value N/A
486230 Pre-E Screen 1st Trimester 486430 UtAPI MoM N/A
486230 Pre-E Screen 1st Trimester 486474 PAPP-A Value ng/mL N/A
486230 Pre-E Screen 1st Trimester 486432 PAPP-A MoM N/A
486230 Pre-E Screen 1st Trimester 486433 PlGF Value pg/mL N/A
486230 Pre-E Screen 1st Trimester 486434 PlGF MoM N/A
486230 Pre-E Screen 1st Trimester 486439 Crown Rump Length (mm) mm N/A
486230 Pre-E Screen 1st Trimester 486440 Crown Rump Length (cm) cm N/A
486230 Pre-E Screen 1st Trimester 486441 Crown Rump Length Twin B (mm) mm N/A
486230 Pre-E Screen 1st Trimester 486442 Crown Rump Length Twin B (cm) cm N/A
486230 Pre-E Screen 1st Trimester 486443 CRL Scan (Date) N/A
486230 Pre-E Screen 1st Trimester 486444 Sonographer ID No. N/A
486230 Pre-E Screen 1st Trimester 486447 Gest. Age on Collection Date N/A
486230 Pre-E Screen 1st Trimester 486448 Gest. Age Based on N/A
486230 Pre-E Screen 1st Trimester 486449 Maternal Age at EDD yr N/A
486230 Pre-E Screen 1st Trimester 486450 Race N/A
486230 Pre-E Screen 1st Trimester 486451 Weight (lbs) lbs N/A
486230 Pre-E Screen 1st Trimester 486452 Weight (kg) kgs N/A
486230 Pre-E Screen 1st Trimester 486453 Height (in) inches N/A
486230 Pre-E Screen 1st Trimester 486454 Height (cm) cm N/A
486230 Pre-E Screen 1st Trimester 486455 BMI N/A
486230 Pre-E Screen 1st Trimester 486456 Number of Fetuses N/A
486230 Pre-E Screen 1st Trimester 486457 Chorionicity N/A
486230 Pre-E Screen 1st Trimester 486458 Previous Preeclampsia N/A
486230 Pre-E Screen 1st Trimester 486459 Family Hx of Preeclampsia N/A
486230 Pre-E Screen 1st Trimester 486460 Assistance Method N/A
486230 Pre-E Screen 1st Trimester 486462 Chronic Hypertension N/A
486230 Pre-E Screen 1st Trimester 486463 Diabetes N/A
486230 Pre-E Screen 1st Trimester 486465 Past No of Pregnancies N/A
486230 Pre-E Screen 1st Trimester 486466 Systemic Lupus Erythematosus N/A
486230 Pre-E Screen 1st Trimester 486467 Smoking Status N/A
486230 Pre-E Screen 1st Trimester 486468 Antiphospholipid Syndrome N/A
486230 Pre-E Screen 1st Trimester 486469 Gestation of Prev Pregnancy N/A
486230 Pre-E Screen 1st Trimester 486472 Note N/A
486230 Pre-E Screen 1st Trimester 486473 PDF N/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486409
Result Code NameResults
UofM
Result LOINC49086-2
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486410
Result Code NameTest Results
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486413
Result Code NamePreeclampsia Interpetation
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486418
Result Code NamePreeclampsia Scr Risk lt 34wk
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486419
Result Code NamePreeclampsia Prescreen Risk
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486420
Result Code NameComments
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486427
Result Code NameMean Arterial Pressure Value
UofMmmHg
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486428
Result Code NameMean Arterial Pressure MoM
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486429
Result Code NameUtAPI Value
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486430
Result Code NameUtAPI MoM
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486474
Result Code NamePAPP-A Value
UofMng/mL
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486432
Result Code NamePAPP-A MoM
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486433
Result Code NamePlGF Value
UofMpg/mL
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486434
Result Code NamePlGF MoM
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486439
Result Code NameCrown Rump Length (mm)
UofMmm
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486440
Result Code NameCrown Rump Length (cm)
UofMcm
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486441
Result Code NameCrown Rump Length Twin B (mm)
UofMmm
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486442
Result Code NameCrown Rump Length Twin B (cm)
UofMcm
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486443
Result Code NameCRL Scan (Date)
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486444
Result Code NameSonographer ID No.
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486447
Result Code NameGest. Age on Collection Date
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486448
Result Code NameGest. Age Based on
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486449
Result Code NameMaternal Age at EDD
UofMyr
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486450
Result Code NameRace
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486451
Result Code NameWeight (lbs)
UofMlbs
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486452
Result Code NameWeight (kg)
UofMkgs
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486453
Result Code NameHeight (in)
UofMinches
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486454
Result Code NameHeight (cm)
UofMcm
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486455
Result Code NameBMI
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486456
Result Code NameNumber of Fetuses
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486457
Result Code NameChorionicity
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486458
Result Code NamePrevious Preeclampsia
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486459
Result Code NameFamily Hx of Preeclampsia
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486460
Result Code NameAssistance Method
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486462
Result Code NameChronic Hypertension
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486463
Result Code NameDiabetes
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486465
Result Code NamePast No of Pregnancies
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486466
Result Code NameSystemic Lupus Erythematosus
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486467
Result Code NameSmoking Status
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486468
Result Code NameAntiphospholipid Syndrome
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486469
Result Code NameGestation of Prev Pregnancy
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486472
Result Code NameNote
UofM
Result LOINCN/A
Order Code486230
Order Code NamePre-E Screen 1st Trimester
Order Loinc
Result Code486473
Result Code NamePDF
UofM
Result LOINCN/A