PD-L1 Quantitative by IHC

Test Number 452366

Test number copied

CPT 88360

Synonyms

PD-L1 Non-specific

Test Details

Methodology

Immunohistochemistry

Result Turnaround Time

1 - 2 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Use

PD-L1 overexpression is associated with adverse prognosis in solid tumors, though specific prognosis varies among different tumor types. The utility of this PD-L1 (22C3) assay in predicting the response to therapy has not been determined for all tumor types, and standardized scoring methods do not exist for all tumor types.

Special Instructions

Note: This test number is used for tracking oncology IHC specimens to the laboratory. Bill codes will be added when testing is complete, based on the processes performed in the laboratory.

Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Formalin-fixed paraffin-embedded (FFPE) tissue block or slides

Volume

One tissue block or five unstained positively charged slides less than one month in age

Minimum Volume

At least three unstained slides sectioned at 4-5 microns

Container

Paraffin block or unstained positive charged slides

Collection Instructions

Paraffin block or unstained slides sectioned of no more than one month age.

Causes for Rejection

Slides sectioned greater than one month prior to test request

References

Wang Q, Liu F, Liu L. Prognostic significance of PD-L1 in solid tumor: an updated meta-analysis. Medicine (Baltimore). 2017 May;96(18):e6369.28471952

Wu P, Wu D, Li L, Chai Y, Huang J. PD-L1 and survival in solid tumors: a meta-analysis. PLoS One. 2015 Jun 26;10(6):e013140.26114883

LOINC® Map

Order Code	Order Code Name	Result Code	Result Code Name	Result LOINC
452366	PD-L1 Quantitative by IHC	452367	Referring Physician	18781-5
452366	PD-L1 Quantitative by IHC	452368	Treating Physician	18781-5
452366	PD-L1 Quantitative by IHC	452369	Client Specimen ID	48767-8
452366	PD-L1 Quantitative by IHC	452370	Contain(s) Received	74384-9
452366	PD-L1 Quantitative by IHC	452371	Clinical Data	55752-0
452366	PD-L1 Quantitative by IHC	452372	Revision Text	N/A
452366	PD-L1 Quantitative by IHC	452373	Body Site	39111-0
452366	PD-L1 Quantitative by IHC	452374	Specimen Type	66746-9
452366	PD-L1 Quantitative by IHC	452375	Interpretation	50595-8
452366	PD-L1 Quantitative by IHC	452376	Test(s) Cancelled	N/A
452366	PD-L1 Quantitative by IHC	452378	Comments:	77202-0
452366	PD-L1 Quantitative by IHC	452379	Reviewing Pathologist	19139-5
452366	PD-L1 Quantitative by IHC	452380	General Results	19146-0
452366	PD-L1 Quantitative by IHC	452381	Result	55229-9
452366	PD-L1 Quantitative by IHC	452382	Non Standard Comments	8251-1
452366	PD-L1 Quantitative by IHC	452383	Additional Notation	48767-8
452366	PD-L1 Quantitative by IHC	452384	Electronically Signed by	19139-5
452366	PD-L1 Quantitative by IHC	452385	Proxy Release by	19139-5
452366	PD-L1 Quantitative by IHC	452386	Disclaimer	62364-5
452366	PD-L1 Quantitative by IHC	452387	PDF	11502-2
452366	PD-L1 Quantitative by IHC	452103	Bill Code Entry Hold	N/A
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452367
Result Code Name	Referring Physician
UofM
Result LOINC	18781-5
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452368
Result Code Name	Treating Physician
UofM
Result LOINC	18781-5
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452369
Result Code Name	Client Specimen ID
UofM
Result LOINC	48767-8
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452370
Result Code Name	Contain(s) Received
UofM
Result LOINC	74384-9
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452371
Result Code Name	Clinical Data
UofM
Result LOINC	55752-0
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452372
Result Code Name	Revision Text
UofM
Result LOINC	N/A
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452373
Result Code Name	Body Site
UofM
Result LOINC	39111-0
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452374
Result Code Name	Specimen Type
UofM
Result LOINC	66746-9
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452375
Result Code Name	Interpretation
UofM
Result LOINC	50595-8
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452376
Result Code Name	Test(s) Cancelled
UofM
Result LOINC	N/A
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452378
Result Code Name	Comments:
UofM
Result LOINC	77202-0
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452379
Result Code Name	Reviewing Pathologist
UofM
Result LOINC	19139-5
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452380
Result Code Name	General Results
UofM
Result LOINC	19146-0
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452381
Result Code Name	Result
UofM
Result LOINC	55229-9
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452382
Result Code Name	Non Standard Comments
UofM
Result LOINC	8251-1
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452383
Result Code Name	Additional Notation
UofM
Result LOINC	48767-8
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452384
Result Code Name	Electronically Signed by
UofM
Result LOINC	19139-5
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452385
Result Code Name	Proxy Release by
UofM
Result LOINC	19139-5
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452386
Result Code Name	Disclaimer
UofM
Result LOINC	62364-5
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452387
Result Code Name	PDF
UofM
Result LOINC	11502-2
Order Code	452366
Order Code Name	PD-L1 Quantitative by IHC
Order Loinc
Result Code	452103
Result Code Name	Bill Code Entry Hold
UofM
Result LOINC	N/A

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