Test Details
Methodology
Determination of enzymatic activity with p-nitrocatechol sulfate
Result Turnaround Time
4 - 14 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Diagnose patient with metachromatic leukodystrophy (MLD)
Special Instructions
Specimens must arrive in the lab within four days of collection.
Limitations
This assay does not identify patients with a rare form of MLD due to cerebroside sulfate activator protein deficiency. Unaffected pseudodeficiency homozygotes and compound heterozygotes cannot be distinguished from affected individuals by this assay. ASA activity may not reflect carrier status.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Specimen Requirements
Specimen
Whole blood
Volume
15 mL
Minimum Volume
10 mL
Container
Yellow-top (ACD) tube
Collection Instructions
Refrigerate after collection. Transport to the testing facility using cool pack or LabCorp transport kit. Do not allow sample to freeze. Sample must arrive in the laboratory within four days of collection.
Stability Requirements
Temperature | Period |
|---|---|
Refrigerated | 4 days |
Reference Range
25.0−90.0 nmol/hour/mg protein
Storage Instructions
Refrigerate.
Causes for Rejection
Quantity not sufficient for analysis; specimen frozen; specimen not received within four days of collection; incorrect specimen collection tube; gross hemolysis; unable to isolate white blood cells
References
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 402396 | Arylsulfatase A Deficiency | 24078-8 | 402397 | Arylsulfatase A activity | nmol/hr/mg prt | 24078-8 |
| 402396 | Arylsulfatase A Deficiency | 24078-8 | 402398 | Interpretation | N/A | |
| 402396 | Arylsulfatase A Deficiency | 24078-8 | 402401 | Director Review | N/A | |
| 402396 | Arylsulfatase A Deficiency | 24078-8 | 402399 | Methodology | N/A | |
| 402396 | Arylsulfatase A Deficiency | 24078-8 | 402308 | Disclaimer: | N/A | |
| Order Code | 402396 | |||||
| Order Code Name | Arylsulfatase A Deficiency | |||||
| Order Loinc | 24078-8 | |||||
| Result Code | 402397 | |||||
| Result Code Name | Arylsulfatase A activity | |||||
| UofM | nmol/hr/mg prt | |||||
| Result LOINC | 24078-8 | |||||
| Order Code | 402396 | |||||
| Order Code Name | Arylsulfatase A Deficiency | |||||
| Order Loinc | 24078-8 | |||||
| Result Code | 402398 | |||||
| Result Code Name | Interpretation | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||
| Order Code | 402396 | |||||
| Order Code Name | Arylsulfatase A Deficiency | |||||
| Order Loinc | 24078-8 | |||||
| Result Code | 402401 | |||||
| Result Code Name | Director Review | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||
| Order Code | 402396 | |||||
| Order Code Name | Arylsulfatase A Deficiency | |||||
| Order Loinc | 24078-8 | |||||
| Result Code | 402399 | |||||
| Result Code Name | Methodology | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||
| Order Code | 402396 | |||||
| Order Code Name | Arylsulfatase A Deficiency | |||||
| Order Loinc | 24078-8 | |||||
| Result Code | 402308 | |||||
| Result Code Name | Disclaimer: | |||||
| UofM | ||||||
| Result LOINC | N/A |