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Thrombosis, Venous Risk Profile

Test Number 385730
Test number copied
CPT 81240; 81241; 85300; 85303; 85306; 85379; 85598; 85610; 85613; 85670; 85730; 86146(x3); 86147(x2). If reflex testing is performed, concomitant CPT codes/charges will apply.

Test Details

Methodology

See individual tests.

Result Turnaround Time

4 - 10 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Related Documents

Test Includes

Anticardiolipin antibodies, IgG and IgM; antithrombin activity; β2-glycoprotein 1 antibodies, IgA, IgG, and IgM; D-dimer; dRVVT screen; factor II (prothrombin) mutation analysis; factor V Leiden mutation analysis; protein C, functional; protein S antigen, free

Specimen Requirements

Specimen

Plasma, frozen and serum, refrigerated, and whole blood or buccal swab kit (Buccal swab collection kit contains instructions for the use of a buccal swab.)

Volume

6 mL frozen plasma (3 mL in each of two tubes) and 2 mL serum and 7 mL whole blood or LabCorp buccal swab kit

Minimum Volume

3 mL frozen plasma and 0.5 mL serum and 3 mL whole blood or two buccal swabs

Container

Blue-top (sodium citrate) tube, gel-barrier tube, lavender-top (EDTA) tube, yellow-top (ACD) tube, or LabCorp buccal swab kit

Collection Instructions

Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.1 Evacuated collection tubes must be filled to completion to ensure a proper blood-to-anticoagulant ratio.2,3 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples.4,5 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette, being careful not to disturb the cells. Deliver to a plastic transport tube, cap, and recentrifuge for 10 minutes. Use a second plastic pipette to remove the plasma, staying clear of the platelets at the bottom of the tube. Transfer the plasma into a LabCorp PP transpak frozen purple tube with screw cap (LabCorp N° 49482). Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.

Storage Instructions

Freeze plasma. Refrigerate serum. Maintain whole blood and buccal swab kit at room temperature or refrigerate.

Patient Preparation

Do not draw from an arm with a heparin lock or heparinized catheter.

References

Alving BM. The antiphospholipid syndrome: Clinical presentation, diagnosis, and patient management. In: Kitchens CS, Alving BM, Kessler CM, eds. Consultative Hemostasis and Thrombosis. Philadelphia, Pa: WB Saunders Co; 2002:181-196.
Baglin T, Gray E, Greaves M, et al. Clinical Guidelines for testing heritable thrombophilia. Br J Haem. 2010; 149:209-220.
Schafer AI, Levine MN, Konkle BA, Kearon C. Thrombotic disorders: Diagnosis and treatment. Hematology (Am Soc Hematol Educ Program). 2003; 520-539. 14633797
Triplett DA. Thrombophilia. In: McClatchey KD, ed. Clinical Laboratory Medicine. 2nd ed. Philadelphia, Pa: Lippincott Williams and Wilkins;2002:1033-1049.

Footnotes

1. Adcock DM, Kressin DC, Marlar RA. Effect of 3.2% vs 3.8% sodium citrate concentration on routine coagulation testing.Am J Clin Pathol. 1997; 107(1):105-110. 8980376
2. Reneke J, Etzell J, Leslie S, et al. Prolonged prothrombin time and activated partial thromboplastin time due to underfilled specimen tubes with 109 mmol/L (3.2%) citrate anticoagulant. Am J Clin Pathol. 1998; 109(6):754-757. 9620035
3. National Committee for Clinical Laboratory Standardization. Collection, Transport, and Processing of Blood Specimens for Coagulation Testing and General Performance of Coagulation Assays; Approved Guideline. 5th ed. Villanova, Pa: NCCLS; 2008. Document H21-A5:28(5).
4. Gottfried EL, Adachi MM. Prothrombin time and activated partial thromboplastin time can be performed on the first tube. Am J Clin Pathol. 1997; 107(6):681-683. 9169665
5.McGlasson DL, More L, Best HA, et al. Drawing specimens for coagulation testing: Is a second tube necessary? Clin Lab Sci. 1999; 12(3):137-139. 10539100

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
385730 Thrombosis, Venous Risk 115206 D-Dimer mg/L FEU 48065-7
385730 Thrombosis, Venous Risk 015040 Antithrombin Activity % 27811-9
385730 Thrombosis, Venous Risk 117705 Protein C-Functional % 27819-2
385730 Thrombosis, Venous Risk 164519 Protein S, Free % 27821-8
385730 Thrombosis, Venous Risk 117012 aPTT sec 14979-9
385730 Thrombosis, Venous Risk 117030 PT sec 5902-2
385730 Thrombosis, Venous Risk 115108 INR 6301-6
385730 Thrombosis, Venous Risk 109009 Thrombin Time sec 3243-3
385730 Thrombosis, Venous Risk 117891 dRVVT sec 6303-2
385730 Thrombosis, Venous Risk 117842 Hexagonal Phase Phospholipid sec 3282-1
385730 Thrombosis, Venous Risk 161812 Anticardiolipin Ab,IgG,Qn GPL U/mL 3181-5
385730 Thrombosis, Venous Risk 161830 Anticardiolipin Ab,IgM,Qn MPL U/mL 3182-3
385730 Thrombosis, Venous Risk 163881 Beta-2 Glycoprotein I Ab, IgG GPI IgG units 16135-6
385730 Thrombosis, Venous Risk 163907 Beta-2 Glycoprotein I Ab, IgM GPI IgM units 16136-4
385730 Thrombosis, Venous Risk 117080 APS Panel Interpretation 50595-8
385730 Thrombosis, Venous Risk 163899 Beta-2 Glycoprotein I Ab, IgA GPI IgA units 21108-6
385730 Thrombosis, Venous Risk 511559 Factor V Leiden Mutation 21667-1
385730 Thrombosis, Venous Risk 512258 Reviewed by: 56850-1
385730 Thrombosis, Venous Risk 511218 Factor II, DNA Analysis 24476-4
385730 Thrombosis, Venous Risk 512253 Reviewed by: 56850-1
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code115206
Result Code NameD-Dimer
UofMmg/L FEU
Result LOINC48065-7
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code015040
Result Code NameAntithrombin Activity
UofM%
Result LOINC27811-9
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code117705
Result Code NameProtein C-Functional
UofM%
Result LOINC27819-2
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code164519
Result Code NameProtein S, Free
UofM%
Result LOINC27821-8
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code117012
Result Code NameaPTT
UofMsec
Result LOINC14979-9
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code117030
Result Code NamePT
UofMsec
Result LOINC5902-2
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code115108
Result Code NameINR
UofM
Result LOINC6301-6
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code109009
Result Code NameThrombin Time
UofMsec
Result LOINC3243-3
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code117891
Result Code NamedRVVT
UofMsec
Result LOINC6303-2
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code117842
Result Code NameHexagonal Phase Phospholipid
UofMsec
Result LOINC3282-1
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code161812
Result Code NameAnticardiolipin Ab,IgG,Qn
UofMGPL U/mL
Result LOINC3181-5
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code161830
Result Code NameAnticardiolipin Ab,IgM,Qn
UofMMPL U/mL
Result LOINC3182-3
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code163881
Result Code NameBeta-2 Glycoprotein I Ab, IgG
UofMGPI IgG units
Result LOINC16135-6
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code163907
Result Code NameBeta-2 Glycoprotein I Ab, IgM
UofMGPI IgM units
Result LOINC16136-4
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code117080
Result Code NameAPS Panel Interpretation
UofM
Result LOINC50595-8
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code163899
Result Code NameBeta-2 Glycoprotein I Ab, IgA
UofMGPI IgA units
Result LOINC21108-6
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code511559
Result Code NameFactor V Leiden Mutation
UofM
Result LOINC21667-1
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code512258
Result Code NameReviewed by:
UofM
Result LOINC56850-1
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code511218
Result Code NameFactor II, DNA Analysis
UofM
Result LOINC24476-4
Order Code385730
Order Code NameThrombosis, Venous Risk
Order Loinc
Result Code512253
Result Code NameReviewed by:
UofM
Result LOINC56850-1
Reflex Table for aPTT
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 117159 aPTT 1:1 Normal Plasma 117159 aPTT 1:1 Normal Plasma sec 5946-9
Reflex 1
Order Code117159
Order NameaPTT 1:1 Normal Plasma
Result Code117159
Result NameaPTT 1:1 Normal Plasma
UofMsec
Result LOINC5946-9
Reflex Table for Thrombin Time
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 117203 Thrombin Neutralization 117203 Thrombin Neutralization sec 46224-2
Reflex 1
Order Code117203
Order NameThrombin Neutralization
Result Code117203
Result NameThrombin Neutralization
UofMsec
Result LOINC46224-2
Reflex Table for dRVVT
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 117924 dRVVT Confirm 117924 dRVVT Confirm ratio 50410-0
Reflex 1
Order Code117924
Order NamedRVVT Confirm
Result Code117924
Result NamedRVVT Confirm
UofMratio
Result LOINC50410-0