Test Details
Methodology
Enzymatic
Result Turnaround Time
Within1 day
Use
Evaluation of hyperlipidemia as an index to coronary artery disease. Investigation of serum lipids is indicated in those with coronary and other arterial disease, especially when it is premature, and in those with family history of atherosclerosis or of hyperlipidemia. In this sense, the expression “premature” is mostly used to include those younger than 40 years of age.
Special Instructions
State the patient's age and sex on the test request form.
Specimen Requirements
Test Includes
Lipid panel; total cholesterol:HDL ratio
Limitations
Patients with obstructive liver disease may develop lipoprotein abnormalities. Serum lipid factors have not been demonstrated to have a strong influence on recurrent stenosis following coronary angioplasty, the pathogenesis of which is presently not well understood. LDL cholesterol cannot be calculated if triglyceride is >800 mg/dL.
Custom Additional Information
Patients with xanthomas should be worked up with lipid panels, but not those with xanthelasmas or xanthofibromas in the sense of dermatofibromas. Those whose fasting serum is lipemic should have a lipid panel, but the serum of a subject with high cholesterol (but normal triglyceride) is not milky in appearance. The patient with high cholesterol (>240 mg/dL) should have a lipid panel. Patients with cholesterol levels between 200−240 mg/dL plus two other coronary heart disease risk factors should also have a lipid panel.1 In addition to application in screening programs for evaluation of risk factors for coronary arterial disease, lipid profiling may lead to detection of some cases of hypothyroidism.
Primary hyperlipoproteinemia includes hypercholesterolemia, a direct risk factor for coronary heart disease.
Secondary hyperlipoproteinemia includes nephrosis, renal failure, obesity, diabetes mellitus, alcoholism, primary biliary cirrhosis, and other types of cholestasis. Decreased lipids are found with some cases of malabsorption, malnutrition, and advanced liver disease. In abetalipoproteinemia, cholesterol is <70 mg/dL.
Specimen
Serum (preferred) or plasma
Volume
1 mL
Minimum Volume
0.7 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube, gel-barrier tube, or green-top (lithium heparin) tube. Do not use oxalate, EDTA, or citrate plasma.
Storage Instructions
Room temperature; if arrival at lab will extend beyond three days, then refrigerate.
Collection Instructions
Separate serum or plasma from cells within 45 minutes of collection. Lipid panels are best avoided for three months following acute myocardial infarction, although cholesterol can be measured in the first 24 hours.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 3 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x2 |
Footnotes
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 221010 | Lipid Panel w/ Chol/HDL Ratio | 24331-1 | 001065 | Cholesterol, Total | mg/dL | 2093-3 |
| 221010 | Lipid Panel w/ Chol/HDL Ratio | 24331-1 | 001172 | Triglycerides | mg/dL | 2571-8 |
| 221010 | Lipid Panel w/ Chol/HDL Ratio | 24331-1 | 011817 | HDL Cholesterol | mg/dL | 2085-9 |
| 221010 | Lipid Panel w/ Chol/HDL Ratio | 24331-1 | 011919 | VLDL Cholesterol Cal | mg/dL | 13458-5 |
| 221010 | Lipid Panel w/ Chol/HDL Ratio | 24331-1 | 012059 | LDL Chol Calc (NIH) | mg/dL | 13457-7 |
| 221010 | Lipid Panel w/ Chol/HDL Ratio | 24331-1 | 011923 | LDL Calc Comment: | N/A | |
| 221010 | Lipid Panel w/ Chol/HDL Ratio | 24331-1 | 100065 | T. Chol/HDL Ratio | ratio | 9830-1 |
| Order Code | 221010 | |||||
| Order Code Name | Lipid Panel w/ Chol/HDL Ratio | |||||
| Order Loinc | 24331-1 | |||||
| Result Code | 001065 | |||||
| Result Code Name | Cholesterol, Total | |||||
| UofM | mg/dL | |||||
| Result LOINC | 2093-3 | |||||
| Order Code | 221010 | |||||
| Order Code Name | Lipid Panel w/ Chol/HDL Ratio | |||||
| Order Loinc | 24331-1 | |||||
| Result Code | 001172 | |||||
| Result Code Name | Triglycerides | |||||
| UofM | mg/dL | |||||
| Result LOINC | 2571-8 | |||||
| Order Code | 221010 | |||||
| Order Code Name | Lipid Panel w/ Chol/HDL Ratio | |||||
| Order Loinc | 24331-1 | |||||
| Result Code | 011817 | |||||
| Result Code Name | HDL Cholesterol | |||||
| UofM | mg/dL | |||||
| Result LOINC | 2085-9 | |||||
| Order Code | 221010 | |||||
| Order Code Name | Lipid Panel w/ Chol/HDL Ratio | |||||
| Order Loinc | 24331-1 | |||||
| Result Code | 011919 | |||||
| Result Code Name | VLDL Cholesterol Cal | |||||
| UofM | mg/dL | |||||
| Result LOINC | 13458-5 | |||||
| Order Code | 221010 | |||||
| Order Code Name | Lipid Panel w/ Chol/HDL Ratio | |||||
| Order Loinc | 24331-1 | |||||
| Result Code | 012059 | |||||
| Result Code Name | LDL Chol Calc (NIH) | |||||
| UofM | mg/dL | |||||
| Result LOINC | 13457-7 | |||||
| Order Code | 221010 | |||||
| Order Code Name | Lipid Panel w/ Chol/HDL Ratio | |||||
| Order Loinc | 24331-1 | |||||
| Result Code | 011923 | |||||
| Result Code Name | LDL Calc Comment: | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||
| Order Code | 221010 | |||||
| Order Code Name | Lipid Panel w/ Chol/HDL Ratio | |||||
| Order Loinc | 24331-1 | |||||
| Result Code | 100065 | |||||
| Result Code Name | T. Chol/HDL Ratio | |||||
| UofM | ratio | |||||
| Result LOINC | 9830-1 |