Test Details
Methodology
Enzyme immunoassay (EIA)
Result Turnaround Time
2 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Diagnosis of histoplasmosis based upon detection of antigen
Limitations
A negative result does not preclude a diagnosis of histoplasmosis. This assay has been documented to cross-react with Blastomyces dermatitidis, Coccidioides immitis, Paracoccidioides brasiliensis and Penicillium marneffei. Positive tests should be confirmed in areas or patient groups where these organisms are endemic or a risk. The following substances may interfere with the assay results: foods that produce color in urine, vaginal cream, caffeine, ascorbic acid, itraconazole, amphotericin B, acetaminophen and acetylsalicylic acid.
Custom Additional Information
Antigen detection may be useful in acute disease, especially in individuals also infected with HIV, who frequently have the disseminated form of histoplasmosis without detectable antibodies to the fungus. In chronic disease, antigen may not be detected due to the low fungal burden. The highest sensitivity for rapidly and accurately diagnosing histoplasmosis in patients with acute pulmonary or disseminated infection can be obtained by testing both urine and serum.
Specimen Requirements
Specimen
Urine (unpreserved)
Volume
5 mL
Minimum Volume
1 mL
Container
Sterile cup or sterile screw-capped vial
Collection Instructions
Collect specimen aseptically
Reference Range
Normal value <0.2 ng/mL
Storage Instructions
Refrigerate. Store specimens at 2°C to 8°C or frozen at -16°C to 24°C for up to 14 days.
Causes for Rejection
Specimen not refrigerated or frozen; insufficient specimen volume; inappropriate specimen source; inappropriate specimen collection device (ie, urine collected/submitted in a maintenance fluid or a preservative such as boric acid); specimen stability exceeded; name discrepancy between the name on the specimen container and the name in the computer or on the requisition
References
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 183560 | Histoplasma Gal'mannan Ag Ur | 48952-6 | 183562 | Histoplasma Gal'mannan Ag Ur | 44524-7 | |
| Order Code | 183560 | |||||
| Order Code Name | Histoplasma Gal'mannan Ag Ur | |||||
| Order Loinc | 48952-6 | |||||
| Result Code | 183562 | |||||
| Result Code Name | Histoplasma Gal'mannan Ag Ur | |||||
| UofM | ||||||
| Result LOINC | 44524-7 |
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 183563 | Histoplasma Gal'mannan Ag Qn U | 183563 | Histoplasma Gal'mannan Ag Qn U | ng/mL | 48952-6 |
| Reflex 1 | ||||||
| Order Code | 183563 | |||||
| Order Name | Histoplasma Gal'mannan Ag Qn U | |||||
| Result Code | 183563 | |||||
| Result Name | Histoplasma Gal'mannan Ag Qn U | |||||
| UofM | ng/mL | |||||
| Result LOINC | 48952-6 | |||||