Test Details
Methodology
Multiplexed nucleic acid amplification
Result Turnaround Time
Performed 7 days per week
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
Cryptococcus neoformans/gattii; Cytomegalovirus; Enterovirus; Escherichia coli K1; Haemophilus influenzae; Herpes simplex virus 1; Herpes simplex virus 2; Human herpesvirus 6; Human parechovirus; Listeria monocytogenes; N. meningitidis (encapsulated); Streptococcus agalactiae; Streptococcus pneumoniae; Varicella zoster virus
Use
This test is used as an aid in the diagnosis of specific agents of meningitis and/or encephalitis; results are meant to be used in conjunction with other clinical, epidemiological and laboratory data.
Limitations
Results are not intended to be used as the sole basis for diagnosis, treatment or other patient management decisions.
Positive results do not rule out co-infection with organisms not included in the FilmArray ME Panel.
The agent detected may not be the definite cause of the disease.
Negative results do not preclude central nervous system infection.
Not all agents of the central nervous system infection are detected by this test, and sensitivity in clinical use may differ from that in the package insert.
Herpesviruses (CMV, HHV-6, HSV-1, HSV-2 and VZV) may exist in latent form and undergo reactivation in various clinical settings. When detected by the Meningitis/Encelphalitis Panel, herpesvirus results should be considered as the likely cause of meningitis/encephalitis only in appropriate clinical context and following expert consultation.
If clinical suspicion for HSV-1/HSV-2 and/or Cryptococcus is high, it is recommended to perform an HSV-specific PCR test (Herpes Simplex Virus (HSV) Types 1/2, Cerebrospinal Fluid (CSF), DNA PCR [139800]) or a Cryptococcus Antigen test (Cryptococcus Antigen [183025]).
Specimen Requirements
Specimen
Cerebrospinal fluid (CSF)
Volume
1 mL unspun CSF
Minimum Volume
0.2 mL unspun CSF
Container
Sterile CSF tube, no preservative or additive
Collection Instructions
Collect specimen via lumbar puncture; do not centrifuge the specimen.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 24 hours (stability provided by manufacturer or literature reference) |
Refrigerated | 7 days (stability provided by manufacturer or literature reference) |
Storage Instructions
Refrigerate.
Causes for Rejection
Specimen stored at room temperature more than 24 hours or specimen stored refrigerated longer than 7 days; specimen other than CSF; specimen centrifuged
References
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 183410 | Meningitis/Encephalitis by NAA | 82180-1 | 183411 | Escherichia coli K1 | 82182-7 | |
| 183410 | Meningitis/Encephalitis by NAA | 82180-1 | 183412 | Haemophilus influenzae | 82183-5 | |
| 183410 | Meningitis/Encephalitis by NAA | 82180-1 | 183413 | Listeria monocytogenes | 82184-3 | |
| 183410 | Meningitis/Encephalitis by NAA | 82180-1 | 183414 | N meningitidis (encapsulated) | 82185-0 | |
| 183410 | Meningitis/Encephalitis by NAA | 82180-1 | 183415 | Streptococcus agalactiae | 82186-8 | |
| 183410 | Meningitis/Encephalitis by NAA | 82180-1 | 183416 | Streptococcus pneumoniae | 82187-6 | |
| 183410 | Meningitis/Encephalitis by NAA | 82180-1 | 183417 | Cytomegalovirus | 82189-2 | |
| 183410 | Meningitis/Encephalitis by NAA | 82180-1 | 183420 | Enterovirus | 82194-2 | |
| 183410 | Meningitis/Encephalitis by NAA | 82180-1 | 183421 | Herpes simplex virus 1 | 82190-0 | |
| 183410 | Meningitis/Encephalitis by NAA | 82180-1 | 183422 | Herpes simplex virus 2 | 82191-8 | |
| 183410 | Meningitis/Encephalitis by NAA | 82180-1 | 183423 | Human herpesvirus 6 | 82192-6 | |
| 183410 | Meningitis/Encephalitis by NAA | 82180-1 | 183424 | Human parechovirus | 82193-4 | |
| 183410 | Meningitis/Encephalitis by NAA | 82180-1 | 183425 | Varicella zoster virus | 82188-4 | |
| 183410 | Meningitis/Encephalitis by NAA | 82180-1 | 183427 | Cryptococcus neoformans/gattii | 82181-9 | |
| Order Code | 183410 | |||||
| Order Code Name | Meningitis/Encephalitis by NAA | |||||
| Order Loinc | 82180-1 | |||||
| Result Code | 183411 | |||||
| Result Code Name | Escherichia coli K1 | |||||
| UofM | ||||||
| Result LOINC | 82182-7 | |||||
| Order Code | 183410 | |||||
| Order Code Name | Meningitis/Encephalitis by NAA | |||||
| Order Loinc | 82180-1 | |||||
| Result Code | 183412 | |||||
| Result Code Name | Haemophilus influenzae | |||||
| UofM | ||||||
| Result LOINC | 82183-5 | |||||
| Order Code | 183410 | |||||
| Order Code Name | Meningitis/Encephalitis by NAA | |||||
| Order Loinc | 82180-1 | |||||
| Result Code | 183413 | |||||
| Result Code Name | Listeria monocytogenes | |||||
| UofM | ||||||
| Result LOINC | 82184-3 | |||||
| Order Code | 183410 | |||||
| Order Code Name | Meningitis/Encephalitis by NAA | |||||
| Order Loinc | 82180-1 | |||||
| Result Code | 183414 | |||||
| Result Code Name | N meningitidis (encapsulated) | |||||
| UofM | ||||||
| Result LOINC | 82185-0 | |||||
| Order Code | 183410 | |||||
| Order Code Name | Meningitis/Encephalitis by NAA | |||||
| Order Loinc | 82180-1 | |||||
| Result Code | 183415 | |||||
| Result Code Name | Streptococcus agalactiae | |||||
| UofM | ||||||
| Result LOINC | 82186-8 | |||||
| Order Code | 183410 | |||||
| Order Code Name | Meningitis/Encephalitis by NAA | |||||
| Order Loinc | 82180-1 | |||||
| Result Code | 183416 | |||||
| Result Code Name | Streptococcus pneumoniae | |||||
| UofM | ||||||
| Result LOINC | 82187-6 | |||||
| Order Code | 183410 | |||||
| Order Code Name | Meningitis/Encephalitis by NAA | |||||
| Order Loinc | 82180-1 | |||||
| Result Code | 183417 | |||||
| Result Code Name | Cytomegalovirus | |||||
| UofM | ||||||
| Result LOINC | 82189-2 | |||||
| Order Code | 183410 | |||||
| Order Code Name | Meningitis/Encephalitis by NAA | |||||
| Order Loinc | 82180-1 | |||||
| Result Code | 183420 | |||||
| Result Code Name | Enterovirus | |||||
| UofM | ||||||
| Result LOINC | 82194-2 | |||||
| Order Code | 183410 | |||||
| Order Code Name | Meningitis/Encephalitis by NAA | |||||
| Order Loinc | 82180-1 | |||||
| Result Code | 183421 | |||||
| Result Code Name | Herpes simplex virus 1 | |||||
| UofM | ||||||
| Result LOINC | 82190-0 | |||||
| Order Code | 183410 | |||||
| Order Code Name | Meningitis/Encephalitis by NAA | |||||
| Order Loinc | 82180-1 | |||||
| Result Code | 183422 | |||||
| Result Code Name | Herpes simplex virus 2 | |||||
| UofM | ||||||
| Result LOINC | 82191-8 | |||||
| Order Code | 183410 | |||||
| Order Code Name | Meningitis/Encephalitis by NAA | |||||
| Order Loinc | 82180-1 | |||||
| Result Code | 183423 | |||||
| Result Code Name | Human herpesvirus 6 | |||||
| UofM | ||||||
| Result LOINC | 82192-6 | |||||
| Order Code | 183410 | |||||
| Order Code Name | Meningitis/Encephalitis by NAA | |||||
| Order Loinc | 82180-1 | |||||
| Result Code | 183424 | |||||
| Result Code Name | Human parechovirus | |||||
| UofM | ||||||
| Result LOINC | 82193-4 | |||||
| Order Code | 183410 | |||||
| Order Code Name | Meningitis/Encephalitis by NAA | |||||
| Order Loinc | 82180-1 | |||||
| Result Code | 183425 | |||||
| Result Code Name | Varicella zoster virus | |||||
| UofM | ||||||
| Result LOINC | 82188-4 | |||||
| Order Code | 183410 | |||||
| Order Code Name | Meningitis/Encephalitis by NAA | |||||
| Order Loinc | 82180-1 | |||||
| Result Code | 183427 | |||||
| Result Code Name | Cryptococcus neoformans/gattii | |||||
| UofM | ||||||
| Result LOINC | 82181-9 |