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For hours, walk-ins and appointments.Cryptococcus Antigen, Cerebrospinal Fluid
CPT:
87899. If reflex titer testing is performed, concomitant CPT codes/charges will apply.
Test Includes
Reflex to titer on positive; reflex to culture when criterion is met.
Special Instructions
Cerebrospinal fluid (CSF) specimens will have a fungus culture performed when antigen-positive (per CAP regulations), if it is not requested separately.
Expected Turnaround Time
1 - 3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Cerebrospinal fluid (CSF)
Volume
1 mL
Minimum Volume
0.5 mL
Container
Sterile plastic (CSF) tube
Storage Instructions
Refrigerated (2°-8°C) or frozen (<−20°C)
Stability Requirements
Temperature | Period |
|---|---|
Refrigerated | 5 days |
Causes for Rejection
Quantity not sufficient for analysis; hemolysis; lipemia; gross bacterial contamination; inadequate labeling; specimen received after prolonged delay (usually >72 hours); inappropriate transport device
Test Details
Use
Aid in establishing the presence of Cryptococcus neoformans or Cryptococcus gattii infection.
Limitations
Endpoint titers may not correlate between different methods of cryptococcal antigen testing. Patients with positive cryptococcal antigen results, therefore, should be monitored using the same assay.
Methodology
Lateral flow immunochromographic assay
References
Binnicker MJ, Jespersen DJ, Bestrom JE, Rollins LO. Comparison of four assays for the detection of cryptococcal antigen. Clin Vaccine Immunol. 2012 Dec; 19(12):1988-1990. 23081814
Klausner JD, Vijayan T, Chiller T. Sensitivity and specificity of a new cryptococcal antigen lateral flow assay in serum and cerebrospinal fluid.MLO. 2013 Mar; 45(3):16,18,20. 23822028
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 183016 | Cryptococcus Antigen, CSF | 70911-3 | 183017 | Cryptococcus Antigen, CSF | 70911-3 | |
| 183016 | Cryptococcus Antigen, CSF | 70911-3 | 183019 | CAP Mandated Reflex to Culture | N/A |
| Reflex Table for Cryptococcus Antigen, CSF | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 183018 | Cryptococcus Ag Titer, CSF | 183018 | Cryptococcus Ag Titer, CSF | 9817-8 | |
| Reflex Table for CAP Mandated Reflex to Culture | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 183022 | Fungus (Mycology) Culture | 183023 | Fungus (Mycology) Culture | 569-4 | |
| Reflex 2 | 183024 | Result | 183027 | Result 1 | 569-4 | |
| Reflex Table for CAP Mandated Reflex to Culture | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 183022 | Fungus (Mycology) Culture | 183023 | Fungus (Mycology) Culture | 569-4 | |
| Reflex 2 | 183024 | Result | 183028 | Result 2 | 569-4 | |
| Reflex Table for CAP Mandated Reflex to Culture | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 183022 | Fungus (Mycology) Culture | 183023 | Fungus (Mycology) Culture | 569-4 | |
| Reflex 2 | 183024 | Result | 183029 | Result 3 | 569-4 | |
| Reflex Table for CAP Mandated Reflex to Culture | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 183022 | Fungus (Mycology) Culture | 183023 | Fungus (Mycology) Culture | 569-4 | |
| Reflex 2 | 183024 | Result | 183030 | Result 4 | 569-4 | |
| Reflex Table for CAP Mandated Reflex to Culture | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 183022 | Fungus (Mycology) Culture | 183023 | Fungus (Mycology) Culture | 569-4 | |
| Reflex 2 | 183024 | Result | 183035 | Antimicrobial Susceptibility | N/A | |
| Reflex Table for CAP Mandated Reflex to Culture | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 183022 | Fungus (Mycology) Culture | 183027 | Result 1 | 569-4 | |
| Reflex Table for CAP Mandated Reflex to Culture | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 183022 | Fungus (Mycology) Culture | 183028 | Result 2 | 569-4 | |
| Reflex Table for CAP Mandated Reflex to Culture | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 183022 | Fungus (Mycology) Culture | 183029 | Result 3 | 569-4 | |
| Reflex Table for CAP Mandated Reflex to Culture | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 183022 | Fungus (Mycology) Culture | 183030 | Result 4 | 569-4 | |
| Reflex Table for CAP Mandated Reflex to Culture | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 183022 | Fungus (Mycology) Culture | 183035 | Antimicrobial Susceptibility | N/A | |
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