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Legionella pneumophila Urinary Antigen

CPT

87449

Test Details

Methodology

Enzyme immunoassay (EIA)

Result Turnaround Time

1 - 3 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Use

This test is used to confirm the diagnosis of Legionella pneumophila serogroup 1 infection.

Limitations

This test will not detect species or serogroups other than Legionella pneumophila serogroup 1.

References

Berdal PP, Farshy CE, Feelley JC. Detection of Legionella pneumophila antigen in urine by enzyme-linked immunospecific assay. J Clin Microbiol. 1979 May; 9(5):575-578. 383744
Kohler RB, Zimmerman SE, Wilson E, et al. Rapid immunoassay diagnosis of Legionnaires' disease: Detection and partial characterization of urinary antigen. Ann Intern Med. 1981 May; 94(5):601-605. 7235392
Reingold AL, Thomason BM, Brake BJ, Thacker L, Wilkinson HW, Kuritsky JN. Legionella pneumonia in the United States: The distribution of serogroups and species causing human illness. J Infect Dis. 1984 May; 149(5):819. 6726009

Custom Additional Information

Legionella pneumophila has been estimated to cause 80% to 85% of Legionella infections, with serogroup 1 accounting for most of these. Current methods of diagnosis for Legionella infection include culture and DFA. All of these other tests require a high quality respiratory specimen to perform this test and, unfortunately, many patients with Legionella infection do not produce sputum. A number of investigators have shown that a specific soluble antigen was present in the urine of patients with Legionnaires' disease, which can be detected both early and late in the disease.

Specimen Requirements

Specimen

Urine

Volume

5 mL

Container

Sterile screw-cap container

Stability Requirements

TemperaturePeriod
Refrigerated

Up to 14 days from collection 

(stability provided by manufacturer or literature reference)

Reference Range

No Legionella pneumophila serogroup 1 antigen detected

Storage Instructions

Refrigerate.

Causes for Rejection

Swab specimen; inappropriate specimen transport device; unlabeled specimen or name discrepancy between specimen and request label; nonurine specimen

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
182246 L. pneumophila Serogp 1 Ur Ag 41499-5 182246 L. pneumophila Serogp 1 Ur Ag 41499-5
Order Code182246
Order Code NameL. pneumophila Serogp 1 Ur Ag
Order Loinc41499-5
Result Code182246
Result Code NameL. pneumophila Serogp 1 Ur Ag
UofM
Result LOINC41499-5