Find Locations
For hours, walk-ins and appointments.Synonyms
- HLA, Transplant
Special Instructions
If you have questions, please call 800-533-1037 (HLA customer service) for assistance in selecting the proper HLA test for the patient.
Expected Turnaround Time
3 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Whole blood or buccal swabs
Volume
7 mL whole blood or four buccal swabs
Minimum Volume
3 mL whole blood or four buccal swabs
Container
Lavender-top (EDTA) tube or four buccal swabs in a sealed envelope (buccal swab kit). When submitting buccal swabs, please use a buccal swab kit provided by LabCorp. To obtain the buccal swab kit, please telephone 800-533-1037.
Storage Instructions
Maintain specimen at room temperature; protect from extreme heat or cold. Do not freeze.
Causes for Rejection
Hemolyzed specimen; clotted specimen; wrong specimen container
Test Details
Use
HLA antigens may be correlated with certain disease states or other clinical conditions. Indicate in clinical information which antigen(s) is of interest. Also used for screening of transplant candidates and potential donors, transfusion of specifically compatible blood products, among others.
High resolution HLA typing is preferred for matching of bone marrow transplant donors and recipients. Other clinical indications may require high resolution typing to rule out alternative allele combinations.
High resolution typing for HLA class I will meet the following criteria: All ambiguities within exons 2 and 3, which defines the antigen recognition site, and exon 4, will be resolved. Those ambiguities that remain will be reported as an allele code.
Limitations
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Methodology
Sequence-based typing (SBT), sequence-specific oligonucleotide probes (SSOP), and/or sequence-specific primers (SSP) as needed to obtain the required resolution.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 176088 | HLA A,B,C (HR) | 019414 | HLA-A | 13298-5 | ||
| 176088 | HLA A,B,C (HR) | 019415 | HLA-A | 13298-5 | ||
| 176088 | HLA A,B,C (HR) | 167339 | HLA-B | 57291-7 | ||
| 176088 | HLA A,B,C (HR) | 167341 | HLA-B | 57291-7 | ||
| 176088 | HLA A,B,C (HR) | 019430 | HLA-C | 42664-3 | ||
| 176088 | HLA A,B,C (HR) | 019431 | HLA-C | 42664-3 | ||
| 176088 | HLA A,B,C (HR) | 167384 | HLA Methodology | 49549-9 |
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CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf