Test Details
Methodology
HLA results are obtained using Next Generation Sequencing (NGS). Supplemental procedures based on Sanger sequence based typing (SBT) may be used as needed to obtain the required resolution.
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HLA results are obtained using Next Generation Sequencing (NGS). Supplemental procedures based on Sanger sequence based typing (SBT) may be used as needed to obtain the required resolution. |
Result Turnaround Time
3 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
HLA antigens may be correlated with certain disease states or other clinical conditions. Indicate in clinical information which antigen(s) is of interest. Also used for screening of transplant candidates and potential donors, transfusion of specifically compatible blood products, among others.
High resolution typing for HLA class I will meet the following criteria: All ambiguities within exons 2 and 3, which defines the antigen recognition site, and exon 4, will be resolved. Those ambiguities that remain will be reported as an allele code.
High resolution typing for HLA class II will meet the following criteria: All ambiguities within exon 2 for DRB1, which defines the antigen recognition site, and exons 2 and 3 for DQB1, will be resolved. Those ambiguities that remain will be reported as an allele code.
Special Instructions
If you have questions, please call 800-533-1037 (HLA customer service) for assistance in selecting the proper HLA test for the patient.
Limitations
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Specimen Requirements
Specimen
Whole blood
Volume
7 mL
Minimum Volume
3 mL
Container
Lavender-top (EDTA) tube
Storage Instructions
Maintain specimen at room temperature; protect from extreme heat or cold. Do not freeze.
Causes for Rejection
Hemolyzed specimen; clotted specimen; wrong specimen container
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 176076 | HLA A,B,C,DRB1 High Resolution | 019414 | HLA-A | 13298-5 | ||
| 176076 | HLA A,B,C,DRB1 High Resolution | 019415 | HLA-A | 13298-5 | ||
| 176076 | HLA A,B,C,DRB1 High Resolution | 167339 | HLA-B | 57291-7 | ||
| 176076 | HLA A,B,C,DRB1 High Resolution | 167341 | HLA-B | 57291-7 | ||
| 176076 | HLA A,B,C,DRB1 High Resolution | 019430 | HLA-C | 42664-3 | ||
| 176076 | HLA A,B,C,DRB1 High Resolution | 019431 | HLA-C | 42664-3 | ||
| 176076 | HLA A,B,C,DRB1 High Resolution | 167313 | DRB1 | 57298-2 | ||
| 176076 | HLA A,B,C,DRB1 High Resolution | 167314 | DRB1 | 57298-2 | ||
| 176076 | HLA A,B,C,DRB1 High Resolution | 167384 | HLA Methodology | 49549-9 | ||
| Order Code | 176076 | |||||
| Order Code Name | HLA A,B,C,DRB1 High Resolution | |||||
| Order Loinc | ||||||
| Result Code | 019414 | |||||
| Result Code Name | HLA-A | |||||
| UofM | ||||||
| Result LOINC | 13298-5 | |||||
| Order Code | 176076 | |||||
| Order Code Name | HLA A,B,C,DRB1 High Resolution | |||||
| Order Loinc | ||||||
| Result Code | 019415 | |||||
| Result Code Name | HLA-A | |||||
| UofM | ||||||
| Result LOINC | 13298-5 | |||||
| Order Code | 176076 | |||||
| Order Code Name | HLA A,B,C,DRB1 High Resolution | |||||
| Order Loinc | ||||||
| Result Code | 167339 | |||||
| Result Code Name | HLA-B | |||||
| UofM | ||||||
| Result LOINC | 57291-7 | |||||
| Order Code | 176076 | |||||
| Order Code Name | HLA A,B,C,DRB1 High Resolution | |||||
| Order Loinc | ||||||
| Result Code | 167341 | |||||
| Result Code Name | HLA-B | |||||
| UofM | ||||||
| Result LOINC | 57291-7 | |||||
| Order Code | 176076 | |||||
| Order Code Name | HLA A,B,C,DRB1 High Resolution | |||||
| Order Loinc | ||||||
| Result Code | 019430 | |||||
| Result Code Name | HLA-C | |||||
| UofM | ||||||
| Result LOINC | 42664-3 | |||||
| Order Code | 176076 | |||||
| Order Code Name | HLA A,B,C,DRB1 High Resolution | |||||
| Order Loinc | ||||||
| Result Code | 019431 | |||||
| Result Code Name | HLA-C | |||||
| UofM | ||||||
| Result LOINC | 42664-3 | |||||
| Order Code | 176076 | |||||
| Order Code Name | HLA A,B,C,DRB1 High Resolution | |||||
| Order Loinc | ||||||
| Result Code | 167313 | |||||
| Result Code Name | DRB1 | |||||
| UofM | ||||||
| Result LOINC | 57298-2 | |||||
| Order Code | 176076 | |||||
| Order Code Name | HLA A,B,C,DRB1 High Resolution | |||||
| Order Loinc | ||||||
| Result Code | 167314 | |||||
| Result Code Name | DRB1 | |||||
| UofM | ||||||
| Result LOINC | 57298-2 | |||||
| Order Code | 176076 | |||||
| Order Code Name | HLA A,B,C,DRB1 High Resolution | |||||
| Order Loinc | ||||||
| Result Code | 167384 | |||||
| Result Code Name | HLA Methodology | |||||
| UofM | ||||||
| Result LOINC | 49549-9 |