Test Details
Methodology
HLA results are obtained using Next Generation Sequencing (NGS). Supplemental procedures based on Sanger sequence based typing (SBT) may be used as needed to obtain the required resolution.
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HLA results are obtained using Next Generation Sequencing (NGS). Supplemental procedures based on Sanger sequence based typing (SBT) may be used as needed to obtain the required resolution. |
Result Turnaround Time
3 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
This test provides data for clients to use for matching transplant donors and recipients. Specific HLA C alleles may be correlated with certain disease states or other clinical conditions. This test may be used to identify specific alleles.
CWD resolution typing for HLA will meet the following criteria:
1. The typing must contain only one unambiguously assigned genotype, or
2. The typing may contain multiple alternative genotypes if one includes two Common and Well Documented (CWD) alleles and the others do not include any CWD allele. Alleles that encode identical protein sequences in the antigen recognition site (ARS) will not be resolved even if they are CWD.
3. Rare or unusual allele combinations may not be ruled out.
4. Allele codes will be reported to include those alleles that are not ruled out.
Common and well documented alleles are defined by Cano et al1 and Mack et al.2
T CWD resolution typing for HLA will meet the following criteria: 1. The typing must contain only one unambiguously assigned genotype, or 2. The typing may contain multiple alternative genotypes if one includes two Common and Well Documented (CWD) alleles and the others do not include any CWD allele. Alleles that encode identical protein sequences in the antigen recognition site (ARS) will not be resolved even if they are CWD. 3. Rare or unusual allele combinations may not be ruled out. 4. Allele codes will be reported to include those alleles that are not ruled out. Common and well documented alleles are defined by Cano et al1 and Mack et al.2 |
This test provides data for clients to use for matching transplant donors and recipients. Specific HLA C alleles may be correlated with certain disease states or other clinical conditions. This test may be used to identify specific alleles. CWD resolution typing for HLA will meet the following criteria: 1. The typing must contain only one unambiguously assigned genotype, or 2. The typing may contain multiple alternative genotypes if one includes two Common and Well Documented (CWD) alleles and the others do not include any CWD allele. Alleles that encode identical protein sequences in the antigen recognition site (ARS) will not be resolved even if they are CWD. 3. Rare or unusual allele combinations may not be ruled out. 4. Allele codes will be reported to include those alleles that are not ruled out. Common and well documented alleles are defined by Cano et al1 and Mack et al.2 |
Special Instructions
If you have questions, please call 800-533-1037 (HLA customer service) for assistance in selecting the proper HLA test for the patient.
Limitations
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
This test was developed |
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. |
Specimen Requirements
Specimen
Whole blood
Volume
7 mL
Minimum Volume
3 mL
Container
Lavender-top (EDTA) tube
Storage Instructions
Maintain specimen at room temperature; protect from extreme heat or cold. Do not freeze.
Causes for Rejection
Hemolyzed specimen; clotted specimen; wrong specimen container
Footnotes
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 167366 | HLA-C (CWD) | 019430 | HLA-C | 42664-3 | ||
| 167366 | HLA-C (CWD) | 019431 | HLA-C | 42664-3 | ||
| 167366 | HLA-C (CWD) | 167384 | HLA Methodology | 49549-9 | ||
| Order Code | 167366 | |||||
| Order Code Name | HLA-C (CWD) | |||||
| Order Loinc | ||||||
| Result Code | 019430 | |||||
| Result Code Name | HLA-C | |||||
| UofM | ||||||
| Result LOINC | 42664-3 | |||||
| Order Code | 167366 | |||||
| Order Code Name | HLA-C (CWD) | |||||
| Order Loinc | ||||||
| Result Code | 019431 | |||||
| Result Code Name | HLA-C | |||||
| UofM | ||||||
| Result LOINC | 42664-3 | |||||
| Order Code | 167366 | |||||
| Order Code Name | HLA-C (CWD) | |||||
| Order Loinc | ||||||
| Result Code | 167384 | |||||
| Result Code Name | HLA Methodology | |||||
| UofM | ||||||
| Result LOINC | 49549-9 |