Test Details
Methodology
Enzyme immunoassay (EIA); indirect immunofluorescence
Result Turnaround Time
3 - 6 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
Endomysial antibody, IgA; tissue transglutaminase (tTG), IgA; total IgA; reflex to tissue transglutaminase (tTG), IgG
Use
Aid in the diagnosis of gluten-sensitive enteropathies
Special Instructions
Reflex testing for tissue transglutaminase (tTG) IgG antibodies is performed if total IgA is decreased.
References
Custom Additional Information
Celiac disease is a gluten enteropathy occurring in both children and adults. The disease is probably underdiagnosed in that it may affect as much as 1% of the population in the US. The condition is characterized by a sensitivity to gluten (found in wheat, barley, and rye) that causes inflammation and atrophy of the villi of the small intestine, malabsorption, etc. This sensitivity to gluten may also be seen in dermatitis herpetiformis. Strict avoidance of gluten in the diet will control disease activity, and antibodies to serum markers will disappear with time.
Specimen Requirements
Specimen
Serum
Volume
3 mL
Minimum Volume
1.75 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 165142 | Celiac Disease Panel | 94494-2 | 164997 | Endomysial Antibody IgA | 10362-2 | |
| 165142 | Celiac Disease Panel | 94494-2 | 164643 | t-Transglutaminase (tTG) IgA | U/mL | 31017-7 |
| 165142 | Celiac Disease Panel | 94494-2 | 001784 | Immunoglobulin A, Qn, Serum | mg/dL | 2458-8 |
| Order Code | 165142 | |||||
| Order Code Name | Celiac Disease Panel | |||||
| Order Loinc | 94494-2 | |||||
| Result Code | 164997 | |||||
| Result Code Name | Endomysial Antibody IgA | |||||
| UofM | ||||||
| Result LOINC | 10362-2 | |||||
| Order Code | 165142 | |||||
| Order Code Name | Celiac Disease Panel | |||||
| Order Loinc | 94494-2 | |||||
| Result Code | 164643 | |||||
| Result Code Name | t-Transglutaminase (tTG) IgA | |||||
| UofM | U/mL | |||||
| Result LOINC | 31017-7 | |||||
| Order Code | 165142 | |||||
| Order Code Name | Celiac Disease Panel | |||||
| Order Loinc | 94494-2 | |||||
| Result Code | 001784 | |||||
| Result Code Name | Immunoglobulin A, Qn, Serum | |||||
| UofM | mg/dL | |||||
| Result LOINC | 2458-8 |
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 164988 | t-Transglutaminase (tTG) IgG | 164989 | t-Transglutaminase (tTG) IgG | U/mL | 32998-7 |
| Reflex 1 | ||||||
| Order Code | 164988 | |||||
| Order Name | t-Transglutaminase (tTG) IgG | |||||
| Result Code | 164989 | |||||
| Result Name | t-Transglutaminase (tTG) IgG | |||||
| UofM | U/mL | |||||
| Result LOINC | 32998-7 | |||||