Test Details
Methodology
Multiplex flow immunoassay
Result Turnaround Time
2 - 3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
Antinuclear antibodies (ANA) will reflex if positive to dsDNA; RNP; Sjögren's A; Sjögren's B; Smith (Sm). If reflex testing is performed, additional charges/CPT code(s) may apply.
References
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Eriksson C, Engstrand S, Sundqvist KG, Rantapää-Dahlqvist S. Autoantibody formation in patients with rheumatoid arthritis treated with anti-TNF alpha. Ann Rheum Dis. 2005 Mar; 64(3):403-407. 15297281
Fulton RJ, McDade RL, Smith PL, Kienker LJ, Kettman JR Jr. Advanced multiplexed analysis with the FlowMetrix system. Clin Chem. 1997 Sep; 43(9):1749-1756. 9299971
Golightly M, Golightly C. Laboratory diagnosis of autoimmune diseases. MLO Med Lab Obs. 2002 Jul; 34(7):12-16, 20. 12134551
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Kavanaugh A, Tomar R, Reveille J, Solomon DH, Homburger HA. Guidelines for clinical use of the antinuclear antibody test and tests for specific autoantibodies to nuclear antigens. American College of Pathologists. Arch Pathol Lab Med. 2000 Jan; 124(1):71-81. 10629135
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Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination; icterus
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 164962 | Antinuclear Ab Multiplex Rfx 5 | 8061-4 | 164862 | ANA Direct | 8061-4 | |
| Order Code | 164962 | |||||
| Order Code Name | Antinuclear Ab Multiplex Rfx 5 | |||||
| Order Loinc | 8061-4 | |||||
| Result Code | 164862 | |||||
| Result Code Name | ANA Direct | |||||
| UofM | ||||||
| Result LOINC | 8061-4 |
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 016123 | ENA+DNA/DS+Sjogren's | 096343 | Anti-DNA (DS) Ab Qn | IU/mL | 5130-0 |
| Reflex 1 | ||||||
| Order Code | 016123 | |||||
| Order Name | ENA+DNA/DS+Sjogren's | |||||
| Result Code | 096343 | |||||
| Result Name | Anti-DNA (DS) Ab Qn | |||||
| UofM | IU/mL | |||||
| Result LOINC | 5130-0 | |||||
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 016123 | ENA+DNA/DS+Sjogren's | 016354 | RNP Antibodies | AI | 29374-6 |
| Reflex 1 | ||||||
| Order Code | 016123 | |||||
| Order Name | ENA+DNA/DS+Sjogren's | |||||
| Result Code | 016354 | |||||
| Result Name | RNP Antibodies | |||||
| UofM | AI | |||||
| Result LOINC | 29374-6 | |||||
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 016123 | ENA+DNA/DS+Sjogren's | 016362 | Smith Antibodies | AI | 11090-8 |
| Reflex 1 | ||||||
| Order Code | 016123 | |||||
| Order Name | ENA+DNA/DS+Sjogren's | |||||
| Result Code | 016362 | |||||
| Result Name | Smith Antibodies | |||||
| UofM | AI | |||||
| Result LOINC | 11090-8 | |||||
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 016123 | ENA+DNA/DS+Sjogren's | 012684 | Sjogren's Anti-SS-A | AI | 17792-3 |
| Reflex 1 | ||||||
| Order Code | 016123 | |||||
| Order Name | ENA+DNA/DS+Sjogren's | |||||
| Result Code | 012684 | |||||
| Result Name | Sjogren's Anti-SS-A | |||||
| UofM | AI | |||||
| Result LOINC | 17792-3 | |||||
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 016123 | ENA+DNA/DS+Sjogren's | 012692 | Sjogren's Anti-SS-B | AI | 17791-5 |
| Reflex 1 | ||||||
| Order Code | 016123 | |||||
| Order Name | ENA+DNA/DS+Sjogren's | |||||
| Result Code | 012692 | |||||
| Result Name | Sjogren's Anti-SS-B | |||||
| UofM | AI | |||||
| Result LOINC | 17791-5 | |||||
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 016123 | ENA+DNA/DS+Sjogren's | 164869 | See below: | N/A | |
| Reflex 1 | ||||||
| Order Code | 016123 | |||||
| Order Name | ENA+DNA/DS+Sjogren's | |||||
| Result Code | 164869 | |||||
| Result Name | See below: | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||