Inflammatory Bowel Disease (IBD) Profile

TEST: 164830
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CPT: 86037; 86671(x2)
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Synonyms

  • Crohn's Disease
  • IBD
  • Ulcerative Colitis

Test Includes

Atypical perinuclear antineutrophil cytoplasmic antibodies (pANCA); Saccharomyces cerevisiae, IgA; Saccharomyces cerevisiae, IgG

Expected Turnaround Time

2 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Related Documents

Specimen Requirements

Specimen

Serum

Volume

1.5 mL

Minimum Volume

0.7 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Collection

Specimen should be free of bacterial contamination, hemolysis, and lipemia.

Storage Instructions

Refrigerate

Causes for Rejection

Hemolysis; lipemia; bacterial contamination

Test Details

Use

Rule out Crohn's disease and ulcerative colitis

Methodology

Atypical ANCA: indirect fluorescent antibody (IFA); Saccharomyces cerevisiae, IgA, and IgG: enzyme immunoassay (EIA)

Reference Interval

• Saccharomyces cerevisiae, IgA: negative: <20.0

• Saccharomyces cerevisiae, IgG: equivocal: 20.1−24.9; positive: ≥25.0

• Atypical antineutrophil cytoplasmic antibodies: negative: <1:20

Additional Information

IgA and IgG antibody testing for S cerevisiae is useful adjunct testing for differentiating Crohn's disease and ulcerative colitis. Nearly 80% of Crohn's disease patients are positive for either IgA or IgG. In ulcerative colitis, <15% are positive for IgG, and <2% are positive for IgA. Fewer than 5% of healthy controls are positive for either IgG or IgA antibody, and no healthy controls had antibody for both. The atypical ANCA pattern has been observed in a significant percentage of patients with ulcerative colitis, primary sclerosing cholangitis, and autoimmune hepatitis.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
164830 Inflammatory Bowel Disease-IBD 87551-8 164658 Saccharomyces cerevisiae, IgG Units 6713-2
164830 Inflammatory Bowel Disease-IBD 87551-8 164659 Saccharomyces cerevisiae, IgA Units 31032-6
164830 Inflammatory Bowel Disease-IBD 87551-8 162402 Atypical pANCA titer 49503-6

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