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For hours, walk-ins and appointments.Tickborne Disease Antibody Profile, Serum
CPT:
86618; 86666(x2); 86753
Synonyms
- Anaplasmosis
- Babesiosis
- Ehrlichiosis
- Lyme
- Lyme disease
Test Includes
Lyme Total Antibody CIA, Babesia microti IgG, Ehrlichia chaffeensis IgG and Anaplasma phagocytophilum IgG
Special Instructions
If reflex test is performed, additional charges/CPT code(s) may apply.
Expected Turnaround Time
1 - 4 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
3 mL
Minimum Volume
1.5 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube, gel-barrier tube or serum transfer tube
Collection
If tube other than a gel-barrier tube is used, transfer separated serum to a plastic transport tube. Do not submit frozen gel-barrier tubes; spin down and transfer separated serum to a plastic transport tube prior to freezing.
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Gross hemolysis; gross lipemia; samples containing particulate matter or exhibiting obvious microbial contamination
Test Details
Use
This test is used for evaluation of patients with a history of, or suspected, tick exposure who are presenting with fever, myalgia, headache, nausea and other nonspecific symptoms. Evaluation of infection with the most common tickborne diseases found in the United States, including Lyme disease (Borrelia burgdorferi), ehrlichiosis (Ehrlichia chaffeensis), anaplasmosis (Anaplasma phagocytophilum) and babesiosis (Babesia microti).
Limitations
Screening of the general population should not be performed. The positive predictive value depends on the likelihood of tickborne disease being present. Testing should only be performed on patients with clinical symptoms of tickborne disease or when exposure is suspected. In general, IgM tests should be disregarded if the patient's symptoms have lasted more than 30 days. If the patient has been sick longer than 30 days, only IgG results should be interpreted. Potential assay interference due to circulating antibodies in patients with Human Ehrlichiosis (HE) and Tick-borne Relapsing Fever (TBRF), Babesiosis, Parvovirus, and EBV infections has been found. Interpret results from these patients with caution.
For Babesia microti Antibodies, IgG and IgM [138315]: This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Anaplasma phagocytophilum, Ehrlichia chaffeensis, and Babesia microti by IFA; Borrelia burgdorferi by CLIA
References
Biggs HM, Behravesh CB, Bradley KK, et al. Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis - United States. MMWR Recomm Rep. 2016 May 13;65(2):1-44.27172113
Krause PJ, Auwaerter PG, Bannuru RR, et al. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis. Clin Infect Dis. 2021 Jan 27;72(2):e49-e64.33252652
Lantos PM, Rumbaugh PM, Bockenstedt LK, et al. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. Clin Infect Dis. 2021 Jan 23;72(1):e1-e48.3341767
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 164705 | Tick-borne Disease Ab Profile | 77165-9 | 164227 | Lyme Total Antibody CIA | 83081-0 | |
| 164705 | Tick-borne Disease Ab Profile | 77165-9 | 138316 | Babesia microti IgG | 16117-4 | |
| 164705 | Tick-borne Disease Ab Profile | 77165-9 | 164681 | E. chaffeensis IgG | 47405-6 | |
| 164705 | Tick-borne Disease Ab Profile | 77165-9 | 164674 | A. phagocytophilum IgG | 23877-4 | |
| 164705 | Tick-borne Disease Ab Profile | 77165-9 | 164706 | Result Comments: | 8251-1 |
| Reflex Table for Lyme Total Antibody CIA | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 164089 | Lyme IgG/IgM | 164230 | Lyme IgG CIA | 16480-6 | |
| Reflex Table for Lyme Total Antibody CIA | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 164089 | Lyme IgG/IgM | 164229 | Lyme IgM CIA | 40612-4 | |
| Reflex Table for Lyme Total Antibody CIA | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 164089 | Lyme IgG/IgM | 164231 | Lyme Interpretation | 101358-0 | |
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