Test Details
Methodology
Enzyme immunoassay (EIA)
Result Turnaround Time
1 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
This test is used to assess immunity against diphtheria by determining levels of circulating antibodies to diphtheria toxin or to measure the immune response, postvaccination, in individuals suspected of immunodeficiency disorders.
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This test is used to assess immunity against diphtheria by determining levels of circulating antibodies to diphtheria toxin or to measure the immune response, postvaccination, in individuals suspected of immunodeficiency disorders. |
Limitations
This procedure is rarely used for confirmation of diphtheria infection; it cannot accurately discriminate antibodies between 0.10 IU/mL and 0.01 IU/mL. Immunity declines with age.
This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.
References
Specimen Requirements
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.25 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Stability Requirements
| Temperature | Period |
|---|---|
| Room temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
| Freeze/thaw cycles | Stable x3 |
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Reference Range
• Nonprotective: <0.1 IU/mL
• Protective: ≥0.1 IU/mL
Storage Instructions
Room temperature
Causes for Rejection
Gross hemolysis; lipemia; bacterial contamination
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 163709 | Diphtheria Antitoxoid Ab | 5116-9 | 163710 | Diphtheria Antitoxoid Ab | IU/mL | 5116-9 |
| Order Code | 163709 | |||||
| Order Code Name | Diphtheria Antitoxoid Ab | |||||
| Order Loinc | 5116-9 | |||||
| Result Code | 163710 | |||||
| Result Code Name | Diphtheria Antitoxoid Ab | |||||
| UofM | IU/mL | |||||
| Result LOINC | 5116-9 |