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Viral Hepatitis Screening and Diagnosis (HAV and HBV)

Test Number 144552
Test number copied
CPT 86704; 86706; 86708; 87340. If reflex testing is performed, concomitant CPT code(s)/charge(s) will apply.
Synonyms
  • Hepatitis
  • Hepatitis A
  • Hepatitis B

Test Details

Methodology

Immunochemiluminometric assay (ICMA)

Result Turnaround Time

1 - 3 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Test Includes

Hepatitis B surface Antigen (HBsAg) Screen, Qualitative [006510]; Hepatitis B Surface Antibody, Qualitative [006395]; Hepatitis B Core Antibody, Total with reflex to IgM [160101]; Hepatitis A Virus (HAV) Antibody, Total with reflex to IgM [144226]

Use

Aid in the diagnosis of viral hepatitis due to infection with HAV and/or HBV.

Special Instructions

If reflex test is performed, additional charges/CPT codes may apply.

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

Limitations

The assays in this panel have not been FDA cleared or approved for the screening of blood or plasma donors. Assay performance characteristics have not been established for immunocompromised or immunosuppressed patients, cord blood, or patients less than 2 years of age.

References

Abara WE, Oaseem A, Schillie S. McMahon BJ, Harris AM, High Value Care Task Force of the American College of Physicians and the Centers for Disease Control and Prevention. Hepatitis B Vaccination, Screening, and Linkage to Care: Best Practice Advice from the American College of Physicians and the Centers for Disease Control and Prevention. Ann Intern Med. 2017 Dec 5;167(11):794-804.29159414
Centers for Disease Control and Prevention. Hepatitis B. CDC web site: www.cdc.gov/hepatitis/hbv/index.htm. Accessed May 2021.
Nelson NP, Weng MK, Hofmeister MG, et al. Prevention of Hepatitis A Virus Infection in the United States: Recommendations of the Advisory Committee on Immunization Practices, 2020. MMWR Recomm Rep. 2020 Jul 3;69(5):1-38.32614811
Terrault NA, Lok ASF, McMahon BJ, et al. Update on Prevention, Diagnosis, and Treatment of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance. Hepatology. 2018 Apr;67(4):1560-1599.29405329
Workowski KA, Bolan GA; Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015 Jun 5;64(RR-03):1-137.26042815

Custom Additional Information

HAV Serology Interpretation: Key - Analyte present: + Analyte absent: - Test not indicated: TNI

Interpretation

HAV Ab, Total

HAV Ab, IgM

Susceptible/no indication of infection

-

TNI

Previously vaccinated against or infected with HAV

+

-

Acute infection

+

+

HBV Serology Interpretation: Key - Analyte present: + Analyte absent: - Test not indicated: TNI

Interpretation

HBsAg

anti-HBs

anti-HBc

IgM anti-HBc

* Multiple possibilities: resolved infection (most common); false-positive anti-HBc (susceptible); "low-level" chronic infection; resolving acute infection.

Susceptible/no evidence of infection

-

-

-

TNI

Immune due to natural resolved infection

-

+

+

TNI

Immune due to vaccination

-

+

-

TNI

Acute infection

+

-

+

+

Chronic infection

+

-

+

-

Intrepretation unclear*

-

-

+

±

Specimen Requirements

Specimen

Serum or EDTA plasma

Volume

7 mL

Minimum Volume

3 mL

Container

Gel-barrier tube, red-top tube or lavender-top (EDTA) tube, serum transfer tube, plasma transfer tube

Collection Instructions

If tube other than a gel-barrier tube is used, transfer separated serum/plasma to a labelled plastic transport tube. Do not freeze gel-barrier tube (pour off serum first).

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Storage Instructions

Room temperature

Causes for Rejection

Heat-inactivated specimens; cord blood; cadaveric specimens; or body fluid other than serum or EDTA plasma; gross hemolysis; excessive lipemia; improper labeling

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
144552 HAV, HBV Panel 95205-1 006510 HBsAg Screen 5196-1
144552 HAV, HBV Panel 95205-1 006408 Hep B Surface Ab, Qual 22322-2
144552 HAV, HBV Panel 95205-1 006718 Hep B Core Ab, Tot 13952-7
144552 HAV, HBV Panel 95205-1 006726 Hep A Ab, Total 13951-9
Order Code144552
Order Code NameHAV, HBV Panel
Order Loinc95205-1
Result Code006510
Result Code NameHBsAg Screen
UofM
Result LOINC5196-1
Order Code144552
Order Code NameHAV, HBV Panel
Order Loinc95205-1
Result Code006408
Result Code NameHep B Surface Ab, Qual
UofM
Result LOINC22322-2
Order Code144552
Order Code NameHAV, HBV Panel
Order Loinc95205-1
Result Code006718
Result Code NameHep B Core Ab, Tot
UofM
Result LOINC13952-7
Order Code144552
Order Code NameHAV, HBV Panel
Order Loinc95205-1
Result Code006726
Result Code NameHep A Ab, Total
UofM
Result LOINC13951-9
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 016105 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code016105
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3
Reflex Table for Hep B Core Ab, Tot
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 126881 HBcIgM 016881 Hep B Core Ab, IgM 24113-3
Reflex 1
Order Code126881
Order NameHBcIgM
Result Code016881
Result NameHep B Core Ab, IgM
UofM
Result LOINC24113-3
Reflex Table for Hep A Ab, Total
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 006734 Hep A Ab, IgM 006734 Hep A Ab, IgM 13950-1
Reflex 1
Order Code006734
Order NameHep A Ab, IgM
Result Code006734
Result NameHep A Ab, IgM
UofM
Result LOINC13950-1