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HBV Baseline Evaluation, HCV Direct-acting Antivirals

Test Number 144547
Test number copied
CPT 86704; 86706; 87340. If reflex testing is performed, concomitant CPT codes/charges will apply.
Synonyms
  • Hepatitis

Test Details

Methodology

Immunochemiluminometric assay (ICMA)

Result Turnaround Time

1 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Test Includes

Hepatitis B Surface Antigen (HBsAg) Screen [006510]; Hepatitis B Surface Antibody (anti-HBs) [006395]; Hepatitis B Core Antibody, Total (anti-HBc) [006718].

Reflex of HBsAg + to: HBV quant DNA [551610].

Use

Risk assessment and management of HBV infection status in patients prior to initiation of HCV treatment with direct-acting antiviral agents.

Special Instructions

If reflex test is performed, additional charges/CPT codes may apply.

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

Limitations

The HBV quantitative real-time PCR assay has a quantitative range of 10 to 1,000,000,000 IU/mL.

References

US Food and Drug Administration. FDA Drug Safety Communication: FDA warns about the risk of hepatitis B reactivating in some patients treated with direct-acting antivirals for hepatitis C. FDA web site: https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-warns-about-risk-hepatitis-b-reactivating-some-patients-treated. Published Oct. 4, 2016. Accessed April 7, 2017.
Whitsett M, Feldman DM, Pan CQ. Risk assessment and management of hepatitis B reactivation from direct-acting antivirals for hepatitis C. Liver Research. 2019 Jun;3(2):75-79. doi.org/10.1016/j.livres.2019.03.002

Specimen Requirements

Specimen

Serum or EDTA plasma

Volume

7.5 mL

Minimum Volume

2.9 mL (Note: This volume does not allow for repeat testing.)

Container

Gel-barrier tube, red top tube, or lavender-top (EDTA) tube

Collection Instructions

Two samples must be submitted.

HBsAg, anti-HBs, anti-HBc Total: If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.

HBV DNA: Centrifuge sample within 24 hours of collection. Transfer serum/plasma to a screw-cap polypropylene transport tube. Ship frozen (preferred). Plasma from a PPT can be frozen in situ.

To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit a separate frozen specimen for each test requested.

Storage Instructions

HBsAg, anti-HBs, anti-HBc Total: Room temperature (preferred) up to 14 days. Refrigerated up to 14 days. Frozen up to 14 days.

HBV DNA: Frozen (preferred) up to 12 weeks. Refrigerated up to 6 days. Room temperature up to 24 hours.

Causes for Rejection

Heat-inactivated specimens; cord blood; cadaveric specimens; or body fluid other than serum or EDTA plasma; gross hemolysis; excessive lipemia; improper labeling

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
144547 HBV Baseline 77190-7 006510 HBsAg Screen 5196-1
144547 HBV Baseline 77190-7 006408 Hep B Surface Ab, Qual 22322-2
144547 HBV Baseline 77190-7 006718 Hep B Core Ab, Tot 13952-7
Order Code144547
Order Code NameHBV Baseline
Order Loinc77190-7
Result Code006510
Result Code NameHBsAg Screen
UofM
Result LOINC5196-1
Order Code144547
Order Code NameHBV Baseline
Order Loinc77190-7
Result Code006408
Result Code NameHep B Surface Ab, Qual
UofM
Result LOINC22322-2
Order Code144547
Order Code NameHBV Baseline
Order Loinc77190-7
Result Code006718
Result Code NameHep B Core Ab, Tot
UofM
Result LOINC13952-7
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 016105 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code016105
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 551610 HBV Real-Time PCR, Quant 551629 HBV IU/mL IU/mL 42595-9
Reflex 1
Order Code551610
Order NameHBV Real-Time PCR, Quant
Result Code551629
Result NameHBV IU/mL
UofMIU/mL
Result LOINC42595-9
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 551610 HBV Real-Time PCR, Quant 551629 HBV IU/mL IU/mL 42595-9
Reflex 1
Order Code551610
Order NameHBV Real-Time PCR, Quant
Result Code551629
Result NameHBV IU/mL
UofMIU/mL
Result LOINC42595-9
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 551610 HBV Real-Time PCR, Quant 551597 log10 HBV IU/mL log10 IU/mL 48398-2
Reflex 1
Order Code551610
Order NameHBV Real-Time PCR, Quant
Result Code551597
Result Namelog10 HBV IU/mL
UofMlog10 IU/mL
Result LOINC48398-2
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 551610 HBV Real-Time PCR, Quant 551724 Test Information: 19147-8
Reflex 1
Order Code551610
Order NameHBV Real-Time PCR, Quant
Result Code551724
Result NameTest Information:
UofM
Result LOINC19147-8
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144405 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code144405
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144405 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code144405
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144405 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code144405
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144405 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code144405
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144405 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code144405
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3