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Hepatitis B Virus (HBV) Patient Management

Test Number 144149
Test number copied
CPT 87340
Synonyms
  • Hepatitis

Test Details

Methodology

Immunochemiluminometric assay (ICMA) (see individual reflex tests for methodologies)

Result Turnaround Time

1 - 7 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Test Includes

Hepatitis B Surface Antigen (HBsAg). Specimens positive for HBsAg reflex to Hepatitis Be Antigen (HBeAg), Hepatitis Be Antibody (anti-HBe), HBV Quantitative DNA, and ALT.

Use

This panel is intended for use in the management of patients with chronic hepatitis B and to assess the efficacy of antiviral treatment. A positive HBsAg test will reflex to HBeAg, anti-HBe, HBV quantitative DNA, and ALT.

Special Instructions

If reflex test is performed, additional charges/CPT code(s) may apply.

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

Limitations

Anti-HBe: Assay performance characteristics have not been established for testing of children less than 17 years of age or pregnant women or in immunocompromized or immunosuppressed patients.

The HBV quantitative real-time PCR assay has a quantitative range of 10 to 1,000,000,000 IU/mL.

Specimen Requirements

Specimen

Serum or EDTA plasma

Volume

9.5 mL (2.5 mL for HBV DNA)

Minimum Volume

3.6 mL (0.7 mL for HBV DNA)

Container

Gel-barrier tube, red top tube, or lavender-top (EDTA) tube

Collection Instructions

Two samples must be submitted.

All tests except DNA: If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube.

HBV DNA: Centrifuge sample within 24 hours of collection. Transfer serum/plasma to a screw-cap polypropylene transport tube. Ship frozen (preferred). Plasma from a PPT can be frozen in situ.

To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit a separate frozen specimen for each test requested.

Storage Instructions

All tests except DNA: Refrigerated (preferred) up to 7 days. Frozen up to 14 days. Room temperature up to 7 days.

HBV DNA: Frozen (preferred) up to 12 weeks. Refrigerated up to 6 days. Room temperature up to 24 hours.

Causes for Rejection

Heat-inactivated specimens; cord blood; cadaveric specimens; or body fluid other than serum or EDTA plasma; gross hemolysis; excessive lipemia; improper labeling

References

Abara WE, Oaseem A, Schillie S. McMahon BJ, Harris AM, High Value Care Task Force of the American College of Physicians and the Centers for Disease Control and Prevention. Hepatitis B Vaccination, Screening, and Linkage to Care: Best Practice Advice from the American College of Physicians and the Centers for Disease Control and Prevention. Ann Intern Med. 2017 Dec 5;167(11):794-804.29159414
Centers for Disease Control and Prevention. Hepatitis B. CDC web site: www.cdc.gov/hepatitis/hbv/index.htm. Accessed May 2021.
Schillie S, Vellozzi C, Reingold A, et al. Prevention of Hepatitis B Virus Infection in the United States: Recommendations of the Advisory Committee on Imunization Practices. MMWR Recomm Rep. 2018 Jan 12;67(1):1-31.29939980
Terrault NA, Lok ASF, McMahon BJ, et al. Update on Prevention, Diagnosis, and Treatment of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance. Hepatology. 2018 Apr;67(4):1560-1599.29405329

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
144149 HBV Patient Mgmt w/rflx 5196-1 006510 HBsAg Screen 5196-1
Order Code144149
Order Code NameHBV Patient Mgmt w/rflx
Order Loinc5196-1
Result Code006510
Result Code NameHBsAg Screen
UofM
Result LOINC5196-1
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 016105 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code016105
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144236 ALT+HBeAb+HBeAg+HBV Qn 001545 ALT (SGPT) IU/L 1742-6
Reflex 1
Order Code144236
Order NameALT+HBeAb+HBeAg+HBV Qn
Result Code001545
Result NameALT (SGPT)
UofMIU/L
Result LOINC1742-6
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144236 ALT+HBeAb+HBeAg+HBV Qn 006619 Hep Be Ag 13954-3
Reflex 1
Order Code144236
Order NameALT+HBeAb+HBeAg+HBV Qn
Result Code006619
Result NameHep Be Ag
UofM
Result LOINC13954-3
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144236 ALT+HBeAb+HBeAg+HBV Qn 006635 Hep Be Ab 13953-5
Reflex 1
Order Code144236
Order NameALT+HBeAb+HBeAg+HBV Qn
Result Code006635
Result NameHep Be Ab
UofM
Result LOINC13953-5
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144236 ALT+HBeAb+HBeAg+HBV Qn 551629 HBV IU/mL IU/mL 42595-9
Reflex 1
Order Code144236
Order NameALT+HBeAb+HBeAg+HBV Qn
Result Code551629
Result NameHBV IU/mL
UofMIU/mL
Result LOINC42595-9
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144236 ALT+HBeAb+HBeAg+HBV Qn 551629 HBV IU/mL IU/mL 42595-9
Reflex 1
Order Code144236
Order NameALT+HBeAb+HBeAg+HBV Qn
Result Code551629
Result NameHBV IU/mL
UofMIU/mL
Result LOINC42595-9
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144236 ALT+HBeAb+HBeAg+HBV Qn 551597 log10 HBV IU/mL log10 IU/mL 48398-2
Reflex 1
Order Code144236
Order NameALT+HBeAb+HBeAg+HBV Qn
Result Code551597
Result Namelog10 HBV IU/mL
UofMlog10 IU/mL
Result LOINC48398-2
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144236 ALT+HBeAb+HBeAg+HBV Qn 551719 Test Information: 19147-8
Reflex 1
Order Code144236
Order NameALT+HBeAb+HBeAg+HBV Qn
Result Code551719
Result NameTest Information:
UofM
Result LOINC19147-8
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144406 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code144406
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144406 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code144406
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144406 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code144406
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144406 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code144406
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144406 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code144406
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144406 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code144406
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144406 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code144406
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144406 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code144406
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3
Reflex Table for HBsAg Screen
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 144406 HBsAg Confirmation 016105 HBsAg Confirmation 7905-3
Reflex 1
Order Code144406
Order NameHBsAg Confirmation
Result Code016105
Result NameHBsAg Confirmation
UofM
Result LOINC7905-3