Test Details
Methodology
Immunochemiluminometric assay (ICMA)
Result Turnaround Time
6 - 12 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
This test is used to identify women who are at high risk for developing preëclampsia.
Footnotes
Custom Additional Information
Insulin-like growth factor-binding protein 1 is a member of the family of structurally homologous proteins that specifically binds and modulates the activities of IGF-1 and IGF-2.1,2 IGFBP-1 is a 25 kilodalton protein that is produced predominantly by hepatocytes and decidualized ovarian endometrium.3 Serum levels of IGFBP-1 exhibit considerable diurnal variation with levels highest early in the morning and lowest in the evening. Serum IGFBP-1 levels are controlled by insulin with the postprandial increase in insulin levels producing a four- to fivefold decrease in IGFBP-1 levels relative to fasting levels.1 IGFBP-1 levels have been shown to be elevated in type 1 diabetics and in patients with insulin resistance syndromes. Type 2 diabetics tend to have low serum IGFBP-1 levels. Patients with growth hormone deficiency tend to have elevated IGFBP-1 levels. Low levels are observed in acromegaly, Cushing disease, and polycystic ovary syndrome. IGFBP-1 is the predominant IGF-binding protein in amniotic fluid and in fetal and maternal circulation.4,5 The levels are high in the fetus and newborn, but decline steadily until puberty. In a recent study of women in the second trimester of pregnancy, IGFBP-1 levels were higher in women who subsequently developed preëclampsia than in matched controls who did not develop the syndrome.6
Specimen Requirements
Specimen
Serum, frozen
Volume
0.5 mL
Minimum Volume
0.1 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection Instructions
Transfer the serum into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze immediately and maintain frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Stability Requirements
Temperature | Period |
---|---|
Room temperature | 1 day |
Refrigerated | 2 days |
Frozen | 16 months |
Freeze/thaw cycles | Stable x6 |
Storage Instructions
Freeze.
Causes for Rejection
Plasma specimens
LOINC® Map
Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
---|---|---|---|---|---|---|
140822 | IGF-BP1 | 140824 | IGF Binding Protein 1 | ng/mL | 12722-5 | |
Order Code | 140822 | |||||
Order Code Name | IGF-BP1 | |||||
Order Loinc | ||||||
Result Code | 140824 | |||||
Result Code Name | IGF Binding Protein 1 | |||||
UofM | ng/mL | |||||
Result LOINC | 12722-5 |