Find Locations
For hours, walk-ins and appointments.Synonyms
- PSA, Complexed
Expected Turnaround Time
2 - 4 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Related Documents
Specimen Requirements
Specimen
Serum
Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Collection
If a red-top tube is used, transfer separated serum to a plastic transport tube.
Storage Instructions
Maintain specimen at room temperature.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Plasma or whole blood specimen; hemolysis
Test Details
Use
PSA is a single-chain glycoprotein normally found in the cytoplasm of the epithelial cells lining the acini and ducts of the prostate gland.1,2 PSA is a neutral serine protease of 240 amino acids involved in the lysis of seminal coagulum.1,3,4 PSA is present in the serum of males with normal, benign hyperplastic and malignant prostate tissue. PSA exists predominantly in circulation in complexes with various protease inhibitors. The most prevalent form of complexed cPSA that can be detected is bound to α1-antichymotrypsin.1,5
cPSA can be useful for determining residual disease and early recurrence after therapy when used in conjunction with other diagnostic indices. cPSA levels increase in men with cancer of the prostate, and after prostatectomy, cPSA levels routinely fall to a very low level.
Limitations
Serum cPSA measurement is not an absolute test for malignancy. The cPSA value should be used in conjunction with information available from clinical evaluation and other diagnostic procedures. Some cases of benign prostatic hypertrophy and prostatitis show elevation of cPSA, but such increases are below those found with adenocarcinoma of prostate stages C and D. Elevations may also be associated with urethral instrumentation, TUR, prostatic needle biopsy, urinary retention, or prostatic infarct.
Results for this test should not be used as absolute evidence of presence or absence of malignant disease without confirmation of the diagnosis by another medically established diagnostic product or procedure. Values obtained with different assay methods or kits cannot be used interchangeably.
Methodology
Siemens Centaur immunochemiluminometric assay (ICMA)
Reference Interval
0.0−3.6 ng/mL
Footnotes
1. Wu JT. Prostate cancer progress. Deciphering benign prostate hyperplasia from cancer. Advance/Laboratory. 1998 Jul 1; 25-32.
2. Wang MC, Valenzuala LA, Murphy GP, Chu TM. Purification of human prostate specific antigen. 1979 [classical article]. J Urol. 2002 Mar; 167(3):1226-1230. 11832702
3. Watt KW, Lee PJ, M'Timkulu T, Chan WP, Loor R. Human prostate-specific antigen: Structural and functional similarity with serine proteases. Proc Natl Acad Sci USA. 1986 May; 83(10):3166-3170. 2422647
4. Lilja H. A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein. J Clin Invest. 1985 Nov; 76(5):1899-1903. 3902893
5. Vashi AR, Oesterling JE. Percent free prostate-specific antigen: Entering a new era in the detection of prostate cancer. Mayo Clin Proc. 1997 Apr; 72(4):337-344. 9121181
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 140674 | PSA, Complexed | 33667-7 | 140685 | PSA, Complexed | ng/mL | 33667-7 |
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