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NMR LipoProfile® With Insulin Resistance Markers Without Lipids (With Graph)

CPT

83704

Test Details

Methodology

Nuclear magnetic resonance (NMR)

Result Turnaround Time

2 - 3 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

NMR LipoProfile® Assay Options Table

Test Includes

Color graphical report; historical reporting (LDL-P); insulin resistance & diabetes risk markers (large VLDL-P, small LDL-P, large HDL-P, VLDL size, LDL size, HDL size); insulin-resistance score; lipoprotein particle number (LDL-P); particle concentration and size (total HDL-P, small LDL-P, LDL size).

Use

NMR LDL-P is a management tool used in appropriate high-risk patients (type 2 diabetes mellitus, metabolic syndrome, CVD risk equivalent, statin-treated patients) to adjudicate response to treatment and guide adjustment in therapy. It is used in conjunction with other lipid measurements and clinical evaluation to aid in the management of lipoprotein disorders associated with cardiovascular disease.

Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Custom Additional Information

The NMR LipoProfile® test is a blood test that directly measures the amount of LDL circulating in the body. “LDL” is low-density lipoprotein and has long been recognized as a major causal factor in the development of heart disease. Although the relationship of increased LDL particle number and plaque buildup in the artery wall has been known since the 1950s, a diagnostic test did not exist to measure LDL particle number (LDL-P). Historically, LDL cholesterol, or LDL-C, has been used to estimate LDL levels to assess a patient’s LDL-related cardiovascular risk and judge an individual’s response to LDL-lowering therapy. The NMR LipoProfile® test reports results for LDL-P, a more reliable measure of LDL that directly counts the number of LDL particles a patient has using NMR technology.

Specimen Requirements

Specimen

Spun NMR LipoTube (preferred), serum from a plain red-top tube, plasma from a lavender-top (EDTA-no gel) or green-top (heparin-no gel) tube. Keep refrigerated and ship with frozen cool packs.

Volume

2 mL

Minimum Volume

1 mL

Container

NMR LipoTube (black-and-yellow-top tube) is the preferred container; plain red-top tube, lavender-top (EDTA-no gel) tube or green-top (heparin-no gel) tube

Collection Instructions

Collect specimen in NMR LipoTube (black-and-yellow-top tube), which is the preferred container. Plain red-top, green-top (heparin-no gel) or lavender-top (EDTA-no gel) tubes also are acceptable. Serum or plasma drawn in gel-barrier collection tubes other than the NMR LipoTube should not be used. The LipoTube is the only acceptable gel-barrier tube. Gently invert tube eight to 10 times to mix contents and allow specimen to clot for 30 minutes upright at room temperature prior to centrifugation (plasma tubes should not clot). Centrifuge specimen within two hours of collection at 1600 to 1800 xg for 10 to 15 minutes to separate serum/plasma from the red cells and to avoid red cell contamination during shipment. If the sample cannot be centrifuged immediately, the sample should be refrigerated (at 2ºC to 8ºC) and centrifuged within 24 hours of collection. Note: Centrifuging the specimen while still cold may negatively affect the migration of the gel to the serum/red cell interface and may increase the likelihood of specimens being contaminated with red cells during shipment. All specimens should be centrifuged by the client prior to shipment to Labcorp to ensure sample integrity. Do not open NMR LipoTube (black-and-yellow-top). Immediately after centrifugation, pipette separated red-top serum or green-top/lavender-top plasma into a transport tube and label accordingly (serum, heparin plasma, EDTA plasma). Keep samples refrigerated until shipment to the laboratory, and ship with frozen cool packs.

Storage Instructions

Refrigerate all acceptable tube types as soon as possible after centrifugation and within 24 hours of collection. Keep refrigerated prior to shipment, and ship on frozen cool packs. Do not store at room temperature. Do not freeze the sample. Sample is stable refrigerated for six days.

Patient Preparation

Patient should be fasting for eight hours.

Causes for Rejection

Unspun specimens; plasma/serum contaminated with red cells; citrated plasma (light blue-top tube); gross hemolysis; specimen received in inappropriate container; specimen stored at room temperature for more than a total preanalytical time of 24 hours; specimen more than six days old

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
123497 NMR LipoProfile+IR+Graph 884294 LDL-P nmol/L 54434-6
123497 NMR LipoProfile+IR+Graph 884296 HDL-P (Total) umol/L 49748-7
123497 NMR LipoProfile+IR+Graph 884297 Small LDL-P nmol/L 43727-7
123497 NMR LipoProfile+IR+Graph 884309 LDL Size nm 17782-4
123497 NMR LipoProfile+IR+Graph 884300 Large VLDL-P nmol/L 43728-5
123497 NMR LipoProfile+IR+Graph 884316 Small LDL-P nmol/L 43727-7
123497 NMR LipoProfile+IR+Graph 884302 Large HDL-P umol/L 43729-3
123497 NMR LipoProfile+IR+Graph 884303 VLDL Size nm 62254-8
123497 NMR LipoProfile+IR+Graph 884317 LDL Size nm 17782-4
123497 NMR LipoProfile+IR+Graph 884305 HDL Size nm 62253-0
123497 NMR LipoProfile+IR+Graph 884314 LP-IR Score 62255-5
123497 NMR LipoProfile+IR+Graph 123811 PDF N/A
123497 NMR LipoProfile+IR+Graph 123469 Historical Reporting N/A
Order Code123497
Order Code NameNMR LipoProfile+IR+Graph
Order Loinc
Result Code884294
Result Code NameLDL-P
UofMnmol/L
Result LOINC54434-6
Order Code123497
Order Code NameNMR LipoProfile+IR+Graph
Order Loinc
Result Code884296
Result Code NameHDL-P (Total)
UofMumol/L
Result LOINC49748-7
Order Code123497
Order Code NameNMR LipoProfile+IR+Graph
Order Loinc
Result Code884297
Result Code NameSmall LDL-P
UofMnmol/L
Result LOINC43727-7
Order Code123497
Order Code NameNMR LipoProfile+IR+Graph
Order Loinc
Result Code884309
Result Code NameLDL Size
UofMnm
Result LOINC17782-4
Order Code123497
Order Code NameNMR LipoProfile+IR+Graph
Order Loinc
Result Code884300
Result Code NameLarge VLDL-P
UofMnmol/L
Result LOINC43728-5
Order Code123497
Order Code NameNMR LipoProfile+IR+Graph
Order Loinc
Result Code884316
Result Code NameSmall LDL-P
UofMnmol/L
Result LOINC43727-7
Order Code123497
Order Code NameNMR LipoProfile+IR+Graph
Order Loinc
Result Code884302
Result Code NameLarge HDL-P
UofMumol/L
Result LOINC43729-3
Order Code123497
Order Code NameNMR LipoProfile+IR+Graph
Order Loinc
Result Code884303
Result Code NameVLDL Size
UofMnm
Result LOINC62254-8
Order Code123497
Order Code NameNMR LipoProfile+IR+Graph
Order Loinc
Result Code884317
Result Code NameLDL Size
UofMnm
Result LOINC17782-4
Order Code123497
Order Code NameNMR LipoProfile+IR+Graph
Order Loinc
Result Code884305
Result Code NameHDL Size
UofMnm
Result LOINC62253-0
Order Code123497
Order Code NameNMR LipoProfile+IR+Graph
Order Loinc
Result Code884314
Result Code NameLP-IR Score
UofM
Result LOINC62255-5
Order Code123497
Order Code NameNMR LipoProfile+IR+Graph
Order Loinc
Result Code123811
Result Code NamePDF
UofM
Result LOINCN/A
Order Code123497
Order Code NameNMR LipoProfile+IR+Graph
Order Loinc
Result Code123469
Result Code NameHistorical Reporting
UofM
Result LOINCN/A