Test Details
Methodology
Oligoclonal banding: IEF; CSF IgG, CSF albumin, and serum IgG: immunologic; serum albumin: spectrophotometry; synthesis rate, ratio, and index by calculation
Result Turnaround Time
3 - 6 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
IgG and albumin quantitation in both serum and spinal fluid samples; CSF, IgG:CSF albumin ratio; CSF IgG index; CSF IgG synthesis rate; oligoclonal banding
Use
Adjunct in aiding clinical diagnosis of multiple sclerosis
Specimen Requirements
Specimen
Serum and cerebrospinal fluid (CSF), collected at the same time
Volume
2 mL serum and 1.5 mL CSF
Minimum Volume
0.8 mL serum and 0.6 mL CSF
Profile Components | CSF Preferred | CSF Minimum | Serum Preferred | Serum Minimum | Notes |
|---|---|---|---|---|---|
*IgG synthesis rate and IgG:albumin ratio (CSF) within the multiple sclerosis profile utilize the same IgG and albumin (CSF and serum) results from the IgG index for calculations; therefore, no additional sample is required. | |||||
Oligoclonal banding | 0.5 mL | 0.1 mL | 0.5 mL | 0.1 mL | Serum and CSF must be collected at the same time. |
IgG index* | 1 mL | 0.5 mL | 1.5 mL | 0.7 mL | Includes IgG and albumin on CSF and serum |
Total sample required: | 1.5 mL | 0.6 mL | 2.0 mL | 0.8 mL | |
Container
Transport tubes
Collection Instructions
Collect serum and CSF at the same time. Avoid contaminating CSF with blood. Centrifuge CSF at 1500xg for 20 minutes and place the supernatant into separate tubes. Ensure that residual fibrin and cellular matter have been removed.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x2 |
Storage Instructions
Room temperature
Causes for Rejection
Plasma instead of serum specimen; serum and CSF not collected within eight hours of each other
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 123075 | Multiple Sclerosis(MS) Profile | 012212 | IgG, Quant, CSF | mg/dL | 2464-6 | |
| 123075 | Multiple Sclerosis(MS) Profile | 012230 | Albumin, CSF | mg/dL | 1746-7 | |
| 123075 | Multiple Sclerosis(MS) Profile | 001081 | Albumin | g/dL | 1751-7 | |
| 123075 | Multiple Sclerosis(MS) Profile | 001776 | Immunoglobulin G, Qn, Serum | mg/dL | 2465-3 | |
| 123075 | Multiple Sclerosis(MS) Profile | 160311 | IgG/Alb Ratio, CSF | 2470-3 | ||
| 123075 | Multiple Sclerosis(MS) Profile | 101124 | CSF IgG Index | 14117-6 | ||
| 123075 | Multiple Sclerosis(MS) Profile | 085937 | IgG, Syn Rate,CSF | mg/day | 14116-8 | |
| 123075 | Multiple Sclerosis(MS) Profile | 111237 | Oligoclonal Bands | N/A | ||
| 123075 | Multiple Sclerosis(MS) Profile | 111666 | Oligoclonal Bands | 48668-8 | ||
| 123075 | Multiple Sclerosis(MS) Profile | 120173 | CSF/Serum Alb. Index | 1756-6 | ||
| Order Code | 123075 | |||||
| Order Code Name | Multiple Sclerosis(MS) Profile | |||||
| Order Loinc | ||||||
| Result Code | 012212 | |||||
| Result Code Name | IgG, Quant, CSF | |||||
| UofM | mg/dL | |||||
| Result LOINC | 2464-6 | |||||
| Order Code | 123075 | |||||
| Order Code Name | Multiple Sclerosis(MS) Profile | |||||
| Order Loinc | ||||||
| Result Code | 012230 | |||||
| Result Code Name | Albumin, CSF | |||||
| UofM | mg/dL | |||||
| Result LOINC | 1746-7 | |||||
| Order Code | 123075 | |||||
| Order Code Name | Multiple Sclerosis(MS) Profile | |||||
| Order Loinc | ||||||
| Result Code | 001081 | |||||
| Result Code Name | Albumin | |||||
| UofM | g/dL | |||||
| Result LOINC | 1751-7 | |||||
| Order Code | 123075 | |||||
| Order Code Name | Multiple Sclerosis(MS) Profile | |||||
| Order Loinc | ||||||
| Result Code | 001776 | |||||
| Result Code Name | Immunoglobulin G, Qn, Serum | |||||
| UofM | mg/dL | |||||
| Result LOINC | 2465-3 | |||||
| Order Code | 123075 | |||||
| Order Code Name | Multiple Sclerosis(MS) Profile | |||||
| Order Loinc | ||||||
| Result Code | 160311 | |||||
| Result Code Name | IgG/Alb Ratio, CSF | |||||
| UofM | ||||||
| Result LOINC | 2470-3 | |||||
| Order Code | 123075 | |||||
| Order Code Name | Multiple Sclerosis(MS) Profile | |||||
| Order Loinc | ||||||
| Result Code | 101124 | |||||
| Result Code Name | CSF IgG Index | |||||
| UofM | ||||||
| Result LOINC | 14117-6 | |||||
| Order Code | 123075 | |||||
| Order Code Name | Multiple Sclerosis(MS) Profile | |||||
| Order Loinc | ||||||
| Result Code | 085937 | |||||
| Result Code Name | IgG, Syn Rate,CSF | |||||
| UofM | mg/day | |||||
| Result LOINC | 14116-8 | |||||
| Order Code | 123075 | |||||
| Order Code Name | Multiple Sclerosis(MS) Profile | |||||
| Order Loinc | ||||||
| Result Code | 111237 | |||||
| Result Code Name | Oligoclonal Bands | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||
| Order Code | 123075 | |||||
| Order Code Name | Multiple Sclerosis(MS) Profile | |||||
| Order Loinc | ||||||
| Result Code | 111666 | |||||
| Result Code Name | Oligoclonal Bands | |||||
| UofM | ||||||
| Result LOINC | 48668-8 | |||||
| Order Code | 123075 | |||||
| Order Code Name | Multiple Sclerosis(MS) Profile | |||||
| Order Loinc | ||||||
| Result Code | 120173 | |||||
| Result Code Name | CSF/Serum Alb. Index | |||||
| UofM | ||||||
| Result LOINC | 1756-6 |