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Cystatin C

CPT

82610

Test Details

Methodology

Turbidimetric (directly traceable to ERM-DA471/IFCC, the international standard reference material)

Result Turnaround Time

3 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Use

Since it is formed at a constant rate and freely filtered by the healthy kidney, cystatin C is a good marker of renal function. Serum concentrations of cystatin C are almost totally dependent on glomerular filtration rate (GFR).1,2 A reduction in GFR causes a rise in the concentration of cystatin C.

Limitations

Cystatin C has not been shown to be affected by factors such as muscle mass and nutrition, factors which have been demonstrated to affect creatinine values. In addition, a rise in creatinine does not become evident until the GFR has fallen by approximately 50%.

Footnotes

1. Grubb A. Diagnostic value of analysis of cystatin C and protein HC in biological fluids. Clin Nephrol. 1992; 38(Suppl 1):S20-7. 1284235
2. Coll E, Botey A, Alvarez L, et al. Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment. Am J Kidney Dis. 2000; 36:29-34.10873868

Specimen Requirements

Specimen

Serum (preferred) or plasma

Volume

1 mL

Minimum Volume

0.5 mL

Container

Gel-barrier tube or green-top (heparin) tube

Collection Instructions

If green-top (heparin) tube is used, separate plasma from red blood cells and transfer plasma to a transfer tube.

Stability Requirements

TemperaturePeriod
Room temperature7 days at 15°C to 25°C (stability provided by manufacturer or literature reference)
Refrigerated7 days at 2°C to 8°C (stability provided by manufacturer or literature reference)
Frozen6 months at -20°C (stability provided by manufacturer or literature reference)
Freeze/thaw cyclesStable x1 (stability provided by manufacturer or literature reference)

Reference Range

See table.

AgeRange (mg/L)
0 to 1 yNot established
2 to 50 y0.60−1.00
51 to 60 y0.67−1.14
61 to 70 y0.72−1.16
71 to 80 y0.78–1.15
>80 y0.87–1.12

Storage Instructions

Room temperature

Causes for Rejection

Specimen other than serum or heparinized plasma; grossly hemolyzed (>1,000 mg/dL Hgb) samples; excessive turbidity and clots in samples

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
121251 Cystatin C 33863-2 121252 Cystatin C mg/L 33863-2
Order Code121251
Order Code NameCystatin C
Order Loinc33863-2
Result Code121252
Result Code NameCystatin C
UofMmg/L
Result LOINC33863-2