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Porphyrins, Quantitative, Random Urine

CPT 84120
Synonyms
  • Coproporphyrin
  • Uroporphyrin

Test Details

Methodology

High-pressure liquid chromatography (HPLC) with fluorometric detection

Result Turnaround Time

3 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Test Includes

Coproporphyrins I and III; uroporphyrins; hepatocarboxylporphyrins; hexacarboxylporphyrins; pentacarboxylporphyrins

Use

Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Evaluation of neurologic and/or psychiatric symptoms associated with acute porphyrias, such as acute intermittent porphyria (AIP), requires urine porphobilinogen (PBG) testing. Refer to Porphobilinogen (PBG), Quantitative, Random Urine [003065].

For initial evaluation of porphyrias. Use Porphyrins, Quantitative, 24-Hour Urine [003194] to follow up random urine abnormal results.

Limitations

See Porphyrins, Quantitative, 24-Hour Urine [003194].

Footnotes

1. Woods JS. Altered porphyrin metabolism as a biomarker of mercury exposure and toxicity. Can J Physiol Pharmacol. 1996 Feb; 74(2):210-215.8723034

Custom Additional Information

Excess urinary porphyrin excretion, or porphyrinuria, results from inhibition of key enzymatic steps in such clinical conditions as genetic deficiencies in heme production enzymes, hepatitis, renal disease, and erythroid disease, as well as by heavy metal inhibition of heme enzyme synthesis.1 Both in experimental animals and in humans exposed to heavy metals, elevated levels of porphyrins have been found in urine.1

Specimen Requirements

Specimen

Urine (random); protected from light

Volume

2 mL

Minimum Volume

1.5 mL

Container

12-mL amber plastic transport tube without preservative

Collection Instructions

Transfer required aliquot into a LabCorp amber plastic transport tube with amber cap (LabCorp No. 23598). (If amber transport tubes are unavailable, cover transport tube completely, top and bottom, with aluminum foil. Identify specimen with patient's name directly on the amber transport tube and on the outside of the aluminum foil. Secure with tape.) Specimen must be kept refrigerated during transport.

Stability Requirements

Temperature

Period

Room temperature

Unstable

Refrigerated

7 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Reference Range

• Coproporphyrin (CP) I: 0−15 μg/L

• Coproporphyrin (CP) III: 0−49 μg/L

• Heptacarboxylporphyrins (7-CP): 0−2 μg/L

• Hexacarboxylporphyrins (6-CP): 0−1 μg/L

• Pentacarboxylporphyrins (5-CP): 0−2 μg/L

• Uroporphyrins (UP): 0−20 μg/L

Storage Instructions

Refrigerate and protect from light.

Causes for Rejection

Stored specimen not refrigerated; specimen exposed to light; acid preservative; pH <3

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
120980 Porphyrins, Qn, Random U 120988 Uroporphyrins (UP) ug/L 11228-4
120980 Porphyrins, Qn, Random U 120989 Heptacarboxyl (7-CP) ug/L 2407-5
120980 Porphyrins, Qn, Random U 120990 Hexacarboxyl (6-CP) ug/L 27400-1
120980 Porphyrins, Qn, Random U 120991 Pentacarboxyl (5-CP) ug/L 11221-9
120980 Porphyrins, Qn, Random U 120992 Coproporphyrin (CP) I ug/L 9343-5
120980 Porphyrins, Qn, Random U 120993 Coproporphyrin (CP) III ug/L 9345-0
Order Code120980
Order Code NamePorphyrins, Qn, Random U
Order Loinc
Result Code120988
Result Code NameUroporphyrins (UP)
UofMug/L
Result LOINC11228-4
Order Code120980
Order Code NamePorphyrins, Qn, Random U
Order Loinc
Result Code120989
Result Code NameHeptacarboxyl (7-CP)
UofMug/L
Result LOINC2407-5
Order Code120980
Order Code NamePorphyrins, Qn, Random U
Order Loinc
Result Code120990
Result Code NameHexacarboxyl (6-CP)
UofMug/L
Result LOINC27400-1
Order Code120980
Order Code NamePorphyrins, Qn, Random U
Order Loinc
Result Code120991
Result Code NamePentacarboxyl (5-CP)
UofMug/L
Result LOINC11221-9
Order Code120980
Order Code NamePorphyrins, Qn, Random U
Order Loinc
Result Code120992
Result Code NameCoproporphyrin (CP) I
UofMug/L
Result LOINC9343-5
Order Code120980
Order Code NamePorphyrins, Qn, Random U
Order Loinc
Result Code120993
Result Code NameCoproporphyrin (CP) III
UofMug/L
Result LOINC9345-0