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Disseminated Intravascular Coagulation (DIC) Profile

CPT 85049; 85362; 85379; 85384; 85610; 85730
Synonyms
  • DIC Profile

Test Details

Methodology

See individual tests.

Result Turnaround Time

2 - 3 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Procedures for Hemostasis and Thrombosis: A Clinical Test Compendium

Test Includes

D-dimer; fibrinogen; fibrinogen degradation products (FDP), plasma; platelet count; partial thromboplastin time (PTT); prothrombin time (PT)

Use

Identify the presence and follow the course of disseminated intravascular coagulation (DIC)

Special Instructions

If the patient's hematocrit exceeds 55%, the volume of citrate in the collection tube must be adjusted. Refer to Coagulation Collection Procedures for directions.

Footnotes

1. Adcock DM, Kressin DC, Marlar RA. Effect of 3.2% vs 3.8% sodium citrate concentration on routine coagulation testing. Am J Clin Pathol. 1997 Jan; 107(1):105-110. 8980376
2. Reneke J, Etzell J, Leslie S, Ng VL, Gottfried EL. Prolonged prothrombin time and activated partial thromboplastin time due to underfilled specimen tubes with 109 mmol/L (3.2%) citrate anticoagulant. Am J Clin Pathol. 1998 Jun; 109(6):754-757. 9620035
3. National Committee for Clinical Laboratory Standardization. Collection, Transport, and Processing of Blood Specimens for Coagulation Testing and General Performance of Coagulation Assays; Approved Guideline. 5th ed. Villanova, Pa: NCCLS; 2008. Document H21-A5:28(5).
4. Gottfried EL, Adachi MM. Prothrombin time and activated partial thromboplastin time can be performed on the first tube. Am J Clin Pathol. 1997 Jun; 107(6):681-683. 9169665
5. McGlasson DL, More L, Best HA, Norris WL, Doe RH, Ray H. Drawing specimens for coagulation testing: Is a second tube necessary? Clin Lab Sci. 1999 May-Jun; 12(3):137-139. 10539100

References

Carey MJ, Rodgers GM. Disseminated intravascular coagulation: Clinical and laboratory aspects. Am J Hematol. 1998 Sep; 59(1):65-73. 9723580
Mammen EF. Disseminated intravascular coagulation (DIC). Clin Lab Sci. 2000 Fall; 13(4):239-245. 11586511
Yu M, Nardella A, Pechet L. Screening tests of disseminated intravascular coagulation: Guidelines for rapid and specific laboratory diagnosis. Crit Care Med. 2000 Jun; 28(6):1777-1780. 10890618

Specimen Requirements

Specimen

Whole blood and plasma, frozen

Volume

5 mL EDTA whole blood, one citrated whole blood tube, and two transfer tubes with 1 mL frozen sodium citrate plasma in each tube

Container

Lavender-top (EDTA) tube and blue-top (sodium citrate) tubes

Collection Instructions

Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate.1 Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio.2,3 The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples.4,5 When noncitrate tubes are collected for other tests, collect sterile and nonadditive (red-top) tubes prior to citrate (blue-top) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-top tube. Gel-barrier tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge and carefully remove the plasma using a plastic transfer pipette, being careful not to disturb the cells. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze immediately and maintain frozen until tested.

Please print and use the Volume Guide for Coagulation Testing to ensure proper draw volume.

Storage Instructions

Maintain whole blood at room temperature. Freeze plasma.

Patient Preparation

None

Causes for Rejection

Severe hemolysis; improper labeling; clotted specimen; specimen diluted with IV fluids; samples thawed in transit; improper sample type; sample out of stability

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
116012 DIC Profile 001610 Fibrinogen Activity mg/dL 3255-7
116012 DIC Profile 115402 FDP, Plasma ug/mL 30226-5
116012 DIC Profile 115107 INR 6301-6
116012 DIC Profile 015289 Prothrombin Time sec 5902-2
116012 DIC Profile 015116 aPTT sec 14979-9
116012 DIC Profile 015172 Platelets x10E3/uL 777-3
116012 DIC Profile 115206 D-Dimer mg/L FEU 48065-7
Order Code116012
Order Code NameDIC Profile
Order Loinc
Result Code001610
Result Code NameFibrinogen Activity
UofMmg/dL
Result LOINC3255-7
Order Code116012
Order Code NameDIC Profile
Order Loinc
Result Code115402
Result Code NameFDP, Plasma
UofMug/mL
Result LOINC30226-5
Order Code116012
Order Code NameDIC Profile
Order Loinc
Result Code115107
Result Code NameINR
UofM
Result LOINC6301-6
Order Code116012
Order Code NameDIC Profile
Order Loinc
Result Code015289
Result Code NameProthrombin Time
UofMsec
Result LOINC5902-2
Order Code116012
Order Code NameDIC Profile
Order Loinc
Result Code015116
Result Code NameaPTT
UofMsec
Result LOINC14979-9
Order Code116012
Order Code NameDIC Profile
Order Loinc
Result Code015172
Result Code NamePlatelets
UofMx10E3/uL
Result LOINC777-3
Order Code116012
Order Code NameDIC Profile
Order Loinc
Result Code115206
Result Code NameD-Dimer
UofMmg/L FEU
Result LOINC48065-7
Reflex Table for INR
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 115109 INR (Thromborel-S) 115109 INR (Thromborel-S) 6301-6
Reflex 1
Order Code115109
Order NameINR (Thromborel-S)
Result Code115109
Result NameINR (Thromborel-S)
UofM
Result LOINC6301-6
Reflex Table for Prothrombin Time
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 015290 PT (Thromborel-S) 015290 PT (Thromborel-S) sec 5902-2
Reflex 1
Order Code015290
Order NamePT (Thromborel-S)
Result Code015290
Result NamePT (Thromborel-S)
UofMsec
Result LOINC5902-2