Lactic Acid Dehydrogenase (LD), Body Fluid

Test Number 100156

Test number copied

CPT 83615

Synonyms

Lactate Dehydrogenase, Variable
LD Variable

Test Details

Methodology

Kinetic

Result Turnaround Time

1 - 2 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Use

A fluid LD activity nearly equal to the plasma activity is usually associated with inflammatory processes

Footnotes

1. Hoffman RM, Rogers RM. Serum and lavage lactate dehydrogenase isoenzymes in pulmonary alveolar proteinosis. Am Rev Respir Dis. 1991 Jan; 143(1):42-46. PubMed 1986683

2. Lampl Y, Paniri Y, Eshel Y, Sarova-Pinhas I. Cerebrospinal fluid lactate dehydrogenase levels in early stroke and transient ischemic attacks. Stroke. 1990 Jun; 21(6):854-857. PubMed 2349587

Custom Additional Information

Lactate dehydrogenase (LD) is a normal component of CSF. Increased amounts may occur in association with ischemic necrosis, meningitis, leukemia, metastatic cancer of the CNS, and lymphoma. LDH₁ and LDH₂ are decreased in lavage fluid in pulmonary alveolar proteinosis.¹ One application of LD measurement is the differential diagnosis of intracranial hemorrhage in neonates versus traumatic tap. Lactate dehydrogenase is elevated in proportion to severity of CNS hemorrhage, but unchanged by traumatic tap. CSF LDH is higher in stroke than in transient ischemic attack.²

Specimen Requirements

Specimen

Fluid or cerebrospinal fluid (CSF)

Volume

1 mL fluid or 1 mL CSF

Minimum Volume

0.3 mL

Container

Sterile body fluid container

Stability Requirements

Temperature	Period
Room temperature	14 days
Refrigerated	7 days
Frozen	14 days
Freeze/thaw cycles	Stable x3

Reference Range

• Peritoneal: Not established

• Pleural:

− Transudate: <200 U/L

− Exudate: >200 U/L

• Synovial: <240 U/L

• CSF: Not established

The method performance specifications have not been established for this test in body fluid. The test result should be integrated into the clinical context for interpretation.

Storage Instructions

Room temperature

Causes for Rejection

Improper labeling

LOINC® Map

Order Code	Order Code Name	Order Loinc	Result Code	Result Code Name	UofM	Result LOINC
100156	LD, Body Fluid	14803-1	100156	LD, Body Fluid	IU/L	14803-1
Order Code	100156
Order Code Name	LD, Body Fluid
Order Loinc	14803-1
Result Code	100156
Result Code Name	LD, Body Fluid
UofM	IU/L
Result LOINC	14803-1

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