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Synonyms
- ADB
- Anti-DNase B Antibodies
- DNase-B
- DNase-B Antibodies
- Streptococcal Antibodies
- Streptodornase
Expected Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Maintain specimen at room temperature.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 9 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Gross lipemia that cannot be clarified by ultracentrifugation; heat-inactivated samples; severe hemolysis
Test Details
Use
Provides evidence of an existing or past streptococcal infection
Methodology
Immunonephelometry
Reference Interval
• <1 year: not established
• 1 to 6 years: <78 U/mL
• 7 to 17 years: ≤170 U/mL
• 18 years and older: ≤120 U/mL
Additional Information
ADNase B antibodies react against the exoenzyme desoxyribonuclease B produced by streptococci. The detection of these antibodies provides evidence of an existing or past streptococcal infection (rheumatic fever, scarlet fever, tonsillitis, glomerulonephritis, and others). The antibody reaction against streptococcal DNase B starts later than the antibody production against streptolysin O, but it can then be detected on a greater percentage of patients.1 An increase in the antistreptolysin concentration rarely occurs with skin infections, while a rise in the ADNase B titer can be observed.1-3
Footnotes
1. Hederstedt B, Holm SE, Wadström T. Antibodies after B-Streptococcal infections. In: Medical Laboratory. Marburg, Germany: Behringwerke AG;1979: 7:24-28.
2. Dillon HC Jr, Reeves MS. Streptococcal immune responses in nephritis after skin infections. Am J Med. 1974 Mar; 56(3):333-346. 4813651
3. Kaplan EL, Anthony BF, Chapman SS, Ayoub EM, Wannamaker LW. The influence of the site of infection on the immune response to group A streptococci. J Clin Invest. 1970 Jul; 49(7):1405-1414. 5432372
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 096289 | Anti-DNase B Strep Antibodies | 5133-4 | 123904 | Anti-DNase B Strep Antibodies | U/mL | 5133-4 |
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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf