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Anti-DNase B (Streptococcal) Antibodies

CPT 86215
Synonyms
  • ADB
  • Anti-DNase B Antibodies
  • DNase-B
  • DNase-B Antibodies
  • Streptococcal Antibodies
  • Streptodornase

Test Details

Methodology

Immunonephelometry

Result Turnaround Time

3 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Use

Provides evidence of an existing or past streptococcal infection

Footnotes

1. Hederstedt B, Holm SE, Wadström T. Antibodies after B-Streptococcal infections. In: Medical Laboratory. Marburg, Germany: Behringwerke AG;1979: 7:24-28.
2. Dillon HC Jr, Reeves MS. Streptococcal immune responses in nephritis after skin infections. Am J Med. 1974 Mar; 56(3):333-346. 4813651
3. Kaplan EL, Anthony BF, Chapman SS, Ayoub EM, Wannamaker LW. The influence of the site of infection on the immune response to group A streptococci. J Clin Invest. 1970 Jul; 49(7):1405-1414. 5432372

Custom Additional Information

ADNase B antibodies react against the exoenzyme desoxyribonuclease B produced by streptococci. The detection of these antibodies provides evidence of an existing or past streptococcal infection (rheumatic fever, scarlet fever, tonsillitis, glomerulonephritis, and others). The antibody reaction against streptococcal DNase B starts later than the antibody production against streptolysin O, but it can then be detected on a greater percentage of patients.1 An increase in the antistreptolysin concentration rarely occurs with skin infections, while a rise in the ADNase B titer can be observed.1-3

Specimen Requirements

Specimen

Serum

Volume

1 mL

Minimum Volume

0.5 mL

Container

Red-top tube or gel-barrier tube

Stability Requirements

Temperature

Period

Room temperature

9 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Reference Range

• <1 year: not established

• 1 to 6 years: <78 U/mL

• 7 to 17 years: ≤170 U/mL

• 18 years and older: ≤120 U/mL

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Gross lipemia that cannot be clarified by ultracentrifugation; heat-inactivated samples; severe hemolysis

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
096289 Anti-DNase B Strep Antibodies 5133-4 123904 Anti-DNase B Strep Antibodies U/mL 5133-4
Order Code096289
Order Code NameAnti-DNase B Strep Antibodies
Order Loinc5133-4
Result Code123904
Result Code NameAnti-DNase B Strep Antibodies
UofMU/mL
Result LOINC5133-4