Tramadol and O-Desmethyltramadol, Serum or Plasma

TEST: 071545
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CPT: 80299
Updated on 11/21/2024
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Synonyms

Ultram®; Tramol®; ConZip®

Ultram®; Tramol®; ConZip®

Expected Turnaround Time

3 - 7 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

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Specimen Requirements

Specimen

Serum or plasma

Serum, plasma, or whole blood

Serum or plasma

Volume

2 mL

0.25 mL

2 mL

Minimum Volume

0.5 mL

Container

Red-top (no additive) tube or green-top (heparin) tube; gel-barrier tubes are not recommended

Red-top tube, lavender-top (EDTA) tube, or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.

Red-top (no additive) tube or green-top (heparin) tube; gel-barrier tubes are not recommended

Collection

Transfer separated serum or plasma to a plastic transport tube. Trough levels are most reproducible.

Separate serum or plasma within two hours of collection and transfer to a plastic transport tube.

Transfer separated serum or plasma to a plastic transport tube. Trough levels are most reproducible.

Storage Instructions

Submission/transport (<3 days): Room temperature. For storage beyond three days, specimen should be refrigerated or frozen.

Refrigerate; stable for 14 days. Stable at room temperature or frozen for 14 days.

Submission/transport (<3 days): Room temperature. For storage beyond three days, specimen should be refrigerated or frozen.

Test Details

Use

This test is used for therapeutic drug management.

Relief of moderate to moderately-severe pain. Indications for monitoring include the following: to confirm or identify suspected drug toxicity in chronic use, therapeutic misadventure, or accidental or intentional acute overdose; to aid in the identification of an unknown drug ingested in unknown quantities, drug identification and/or quantitation may be performed as an adjunct for patient management; to monitor selected patient groups at greater risk for analgesic drug toxicity or drug-to-drug interaction; to confirm complete drug absorption and adequate drug elimination as an adjunct to overdose management.

This test is used for therapeutic drug management.

Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Reference Interval

Tramadol: 100-1000 ng/mL

O-desmethyltramadol: up to 200 ng/mL

Tramadol: 100-1000 ng/mL

O-desmethyltramadol: up to 200 ng/mL

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