Test Details
Methodology
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Result Turnaround Time
4 - 6 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Half-life of elimination: approximately three hours. Time to peak, serum: one hour.
Limitations
Opioids is a general term applied to all substances with morphine-like properties and describes naturally-occurring or semisynthetic analgesic alkaloids derived from opium. Some important semisynthetic derivatives of morphine include heroin and its metabolite, 6-acetylmorphine; oxycodone; codeine; hydrocodone; oxymorphone; dihydrocodeine; and hydromorphone. Opiates are used clinically because of their analgesic properties, also causing sedation, euphoria, respiratory depression, orthostatic hypotension, diminished intestinal motility, nausea, and vomiting. Because of these properties, opioids have a high abuse potential, whereby chronic use leads to tolerance and dependence. Clinical monitoring of compliance is effected through measurement of these analytes.
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Specimen Requirements
Specimen
Serum, plasma, or whole blood
Volume
0.3 mL
Minimum Volume
0.1 mL
Container
Red-top tube, lavender-top (EDTA) tube, or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.
Collection Instructions
Separate serum or plasma within one hour of collection and transfer to a plastic transport tube.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Storage Instructions
Room temperature
Causes for Rejection
Gel-barrier tube
References
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 071529 | Codeine and Metabolite | 071527 | Codeine | ng/mL | 3506-3 | |
| 071529 | Codeine and Metabolite | 071528 | Morphine | ng/mL | 3827-3 | |
| Order Code | 071529 | |||||
| Order Code Name | Codeine and Metabolite | |||||
| Order Loinc | ||||||
| Result Code | 071527 | |||||
| Result Code Name | Codeine | |||||
| UofM | ng/mL | |||||
| Result LOINC | 3506-3 | |||||
| Order Code | 071529 | |||||
| Order Code Name | Codeine and Metabolite | |||||
| Order Loinc | ||||||
| Result Code | 071528 | |||||
| Result Code Name | Morphine | |||||
| UofM | ng/mL | |||||
| Result LOINC | 3827-3 |