Test Details
Methodology
Inductively-coupled plasma/mass spectrometry (ICP/MS)
Result Turnaround Time
2 - 4 days
Use
Monitor industrial exposure to cobalt
Special Instructions
Do not use preservative. Preservatives used for routine analysis may contain mercuric oxide (ie, Stabilur), which interferes with all metal testing. If both urinalysis and metal testing are ordered, please submit a separate urine specimen (containing no additive) for the metal testing.
Specimen Requirements
Test Includes
Cobalt, urine; creatinine, urine; cobalt:creatinine ratio
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Specimen
Urine (random or 24-hour)
Volume
5 mL
Minimum Volume
1.5 mL
Container
Plastic urine container, no preservative
Storage Instructions
Maintain specimen at room temperature.
Collection Instructions
Sampling time is end of shift at end of work week. Metals with timing “end of shift at end of work week” (meaning four or five consecutive working days with exposure) are eliminated with half-lives longer than five hours. Such metals accumulate in the body during the work week; therefore, their timing is critical in relation to previous exposures.
Optional protocol: Instruct the patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Avoid contact with metal during collection. Screw the lid on securely.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Reference Range
• Environmental exposure: 1.0−2.0 μg/L; <2.0 μg/g creatinine
• Occupational exposure: BEI® (sampling time is end of shift at end of work week): 15.0 μg/L1
Footnotes
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 071514 | Cobalt, Urine | 071515 | Cobalt, Urine | ug/L | 5628-3 | |
| 071514 | Cobalt, Urine | 071517 | Cobalt, Urine 24 Hr | ug/24 hr | 29916-4 | |
| 071514 | Cobalt, Urine | 723280 | Creatinine(Crt),U | g/L | 2161-8 | |
| 071514 | Cobalt, Urine | 071518 | Cobalt/Creat. Ratio | ug/g creat | 13468-4 | |
| Order Code | 071514 | |||||
| Order Code Name | Cobalt, Urine | |||||
| Order Loinc | ||||||
| Result Code | 071515 | |||||
| Result Code Name | Cobalt, Urine | |||||
| UofM | ug/L | |||||
| Result LOINC | 5628-3 | |||||
| Order Code | 071514 | |||||
| Order Code Name | Cobalt, Urine | |||||
| Order Loinc | ||||||
| Result Code | 071517 | |||||
| Result Code Name | Cobalt, Urine 24 Hr | |||||
| UofM | ug/24 hr | |||||
| Result LOINC | 29916-4 | |||||
| Order Code | 071514 | |||||
| Order Code Name | Cobalt, Urine | |||||
| Order Loinc | ||||||
| Result Code | 723280 | |||||
| Result Code Name | Creatinine(Crt),U | |||||
| UofM | g/L | |||||
| Result LOINC | 2161-8 | |||||
| Order Code | 071514 | |||||
| Order Code Name | Cobalt, Urine | |||||
| Order Loinc | ||||||
| Result Code | 071518 | |||||
| Result Code Name | Cobalt/Creat. Ratio | |||||
| UofM | ug/g creat | |||||
| Result LOINC | 13468-4 |