Test Details
Methodology
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Result Turnaround Time
3 - 6 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
17-Hydroxyprogesterone (17-OHP) in urine is greatly elevated in patients with polycystic ovarian disease and in patients with idiopathic hirsutism.
Special Instructions
Record total 24-hour urine volume on the test request form.
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Custom Additional Information
Wong and coworkers showed that measurement of 17-OHP in 24-hour urine produced results that may be useful for monitoring glucocorticoid and mineralocorticoid therapy in patients with congenital adrenal hyperplasia (CAH).1 Other studies have shown that 17-OHP in 24-hour urine correlated well with serum 17-OHP and suggested that the urine measurement of 17-OHP may be a reliable alternative to serum 17-OHP measurement for monitoring of CAH therapy.2,3
Specimen Requirements
Specimen
Urine (24-hour)
Volume
30 mL aliquot
Minimum Volume
4 mL aliquot
Container
Plastic urine container with 30 mL 6N HCl preservative. Caution: Strong acid. May cause skin burns.
Collection Instructions
Instruct the patient to void at 8 AM and discard the specimen. Preservative must be added to the container prior to the start of collection. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Measure and record total urine volume on the request form. Label container with patient's name, date and time collection started, and date and time collection finished. Keep collection on ice. Remove 20 mL aliquot. pH should be ≤3.
Storage Instructions
Refrigerate
Causes for Rejection
Specimens with no preservative; pH not ≤3.
Footnotes
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 070315 | 17-OH P/Creat Ratio, 24-Hr U | 070312 | 17-OH Progesterone, Urine | ng/dL | 1670-9 | |
| 070315 | 17-OH P/Creat Ratio, 24-Hr U | 070016 | Creatinine, Random U | mg/dL | 2161-8 | |
| 070315 | 17-OH P/Creat Ratio, 24-Hr U | 070316 | 17-OH P 24 Hr, Urine | ug/24 hr | 9616-4 | |
| 070315 | 17-OH P/Creat Ratio, 24-Hr U | 070314 | 17-OH P/Creat Ratio | ng/mg cr | 63042-6 | |
| Order Code | 070315 | |||||
| Order Code Name | 17-OH P/Creat Ratio, 24-Hr U | |||||
| Order Loinc | ||||||
| Result Code | 070312 | |||||
| Result Code Name | 17-OH Progesterone, Urine | |||||
| UofM | ng/dL | |||||
| Result LOINC | 1670-9 | |||||
| Order Code | 070315 | |||||
| Order Code Name | 17-OH P/Creat Ratio, 24-Hr U | |||||
| Order Loinc | ||||||
| Result Code | 070016 | |||||
| Result Code Name | Creatinine, Random U | |||||
| UofM | mg/dL | |||||
| Result LOINC | 2161-8 | |||||
| Order Code | 070315 | |||||
| Order Code Name | 17-OH P/Creat Ratio, 24-Hr U | |||||
| Order Loinc | ||||||
| Result Code | 070316 | |||||
| Result Code Name | 17-OH P 24 Hr, Urine | |||||
| UofM | ug/24 hr | |||||
| Result LOINC | 9616-4 | |||||
| Order Code | 070315 | |||||
| Order Code Name | 17-OH P/Creat Ratio, 24-Hr U | |||||
| Order Loinc | ||||||
| Result Code | 070314 | |||||
| Result Code Name | 17-OH P/Creat Ratio | |||||
| UofM | ng/mg cr | |||||
| Result LOINC | 63042-6 |