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Chromosome Analysis, Products of Conception (POC) With Reflex to SNP Microarray (Reveal®)

Test Number 052065
Test number copied
CPT

Contact CPT coding department at 800-222-7566, ext 6-8400. If reflex testing is performed, concomitant CPT codes/charges will apply.

Test Details

Methodology

Tissue culture following enzymatic digestion of tissue. Standard harvesting and G-banding procedures are used with 20 metaphases examined and two karyotypes prepared. If tissue fails to grow for cytogenetic analysis, SNP microarray analysis is performed with the remaining fresh tissue using the Cytoscan® HD platform, which uses more than 743,000 SNP probes and 1,953,000 NPCN probes with a median spacing of 0.88 kb. For specimens that have failed Cytoscan® HD or specimens that do not have enough DNA to run Cytoscan® HD, SNP microarray analysis is performed using the Oncoscan® FFPE platform. This platform has more than 220,000 SNP probes with a median spacing of 5.0 kb, within the majority of genes.

Result Turnaround Time

13 - 24 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

SNP Microarray Prenatal POC Clinical Questionnaire

Clinical Questionnaire for Prenatal SNP Microarray

Test Includes

Chromosome analysis, SNP microarray reflex

Use

This test is used to evaluate possible chromosomal abnormalities as cause of miscarriage. The SNP assay will detect chromosomal imbalance that could be associated with developmental delay/congenital anomalies. It provides detection of possible uniparental disomy of any chromosome, the percent and location of homozygosity, including the degree of identity by descent. It will also allow the detection of complete or partial molar pregnancies.

Special Instructions

The microarray reflex is designed for specimens that fail to grow in culture. If tissue fails to grow, reflex to whole genome SNP microarray (Reveal®), targeting 2.695 million copy number and allele-specific genome sites, will be initiated. Please include clinical information, previous cytogenetic report or karyotype.

If prior Cell-free DNA/NIPT studies have been performed, include copy of the report.

Call 800-345-4363 if there are any questions.

Limitations

Some products of conception may only contain maternal tissue. An option to confirm presence of fetal tissue before testing is available; see Maternal Cell Contamination [511402]. For the SNP assay, it does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Tissue, skin, ovarian biopsy, products of conception, placental biopsy

Volume

2 to 4 mm³

Container

Submit biopsies in a sterile tube with sterile Ringer's lactate, Hanks' basal salt solution or Labcorp transport medium.

The transport tube (a sterile specimen container with transport medium) is available from Labcorp. Please call customer service at 800-345-4363. Do not use urine containers for shipping.

Saline is not recommended for transport. Do not use urine containers for shipping.

Collection Instructions

Aseptically obtain a small piece of tissue with subepidermal layers. Best results are obtained from placental villi, which remain viable much longer than fetal tissue. This is especially true in stillborn cases in which both cord blood and tissue samples are often not viable. If specimen is a product of conception, submit biopsies in a sterile tube with sterile Ringer's lactate, Hanks' balanced salt solution or Labcorp transport medium.

Storage Instructions

Refrigerate; do not freeze.

Causes for Rejection

Gross contamination; necrotic tissue; specimen in fixative

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
052065 Chromosome POC Rfx CMA 96984-0 052072 Cells Counted 62361-1
052065 Chromosome POC Rfx CMA 96984-0 052073 Cells Karyotyped 55199-4
052065 Chromosome POC Rfx CMA 96984-0 052074 Cells Analyzed 62360-3
052065 Chromosome POC Rfx CMA 96984-0 052075 GTG Band Resolution Achieved 62358-7
052065 Chromosome POC Rfx CMA 96984-0 052077 Cytogenetic Result 62356-1
052065 Chromosome POC Rfx CMA 96984-0 052046 Cytogenetic Interpretation 62357-9
052065 Chromosome POC Rfx CMA 96984-0 052079 Specimen Type 48002-0
052065 Chromosome POC Rfx CMA 96984-0 052047 Director Review: 48672-0
052065 Chromosome POC Rfx CMA 96984-0 052091 Reflex N/A
052065 Chromosome POC Rfx CMA 96984-0 512123 PDF 11502-2
Order Code052065
Order Code NameChromosome POC Rfx CMA
Order Loinc96984-0
Result Code052072
Result Code NameCells Counted
UofM
Result LOINC62361-1
Order Code052065
Order Code NameChromosome POC Rfx CMA
Order Loinc96984-0
Result Code052073
Result Code NameCells Karyotyped
UofM
Result LOINC55199-4
Order Code052065
Order Code NameChromosome POC Rfx CMA
Order Loinc96984-0
Result Code052074
Result Code NameCells Analyzed
UofM
Result LOINC62360-3
Order Code052065
Order Code NameChromosome POC Rfx CMA
Order Loinc96984-0
Result Code052075
Result Code NameGTG Band Resolution Achieved
UofM
Result LOINC62358-7
Order Code052065
Order Code NameChromosome POC Rfx CMA
Order Loinc96984-0
Result Code052077
Result Code NameCytogenetic Result
UofM
Result LOINC62356-1
Order Code052065
Order Code NameChromosome POC Rfx CMA
Order Loinc96984-0
Result Code052046
Result Code NameCytogenetic Interpretation
UofM
Result LOINC62357-9
Order Code052065
Order Code NameChromosome POC Rfx CMA
Order Loinc96984-0
Result Code052079
Result Code NameSpecimen Type
UofM
Result LOINC48002-0
Order Code052065
Order Code NameChromosome POC Rfx CMA
Order Loinc96984-0
Result Code052047
Result Code NameDirector Review:
UofM
Result LOINC48672-0
Order Code052065
Order Code NameChromosome POC Rfx CMA
Order Loinc96984-0
Result Code052091
Result Code NameReflex
UofM
Result LOINCN/A
Order Code052065
Order Code NameChromosome POC Rfx CMA
Order Loinc96984-0
Result Code512123
Result Code NamePDF
UofM
Result LOINC11502-2
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 511037 Microarray 510217 Chromosome Microarray N/A
Reflex 1
Order Code511037
Order NameMicroarray
Result Code510217
Result NameChromosome Microarray
UofM
Result LOINCN/A
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 511037 Microarray 510112 Specimen Type 31208-2
Reflex 1
Order Code511037
Order NameMicroarray
Result Code510112
Result NameSpecimen Type
UofM
Result LOINC31208-2
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 511037 Microarray 510113 # of Genotyping Targets N/A
Reflex 1
Order Code511037
Order NameMicroarray
Result Code510113
Result Name# of Genotyping Targets
UofM
Result LOINCN/A
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 511037 Microarray 510114 Array Type 96984-0
Reflex 1
Order Code511037
Order NameMicroarray
Result Code510114
Result NameArray Type
UofM
Result LOINC96984-0
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 511037 Microarray 510116 Diagnosis 48000-4
Reflex 1
Order Code511037
Order NameMicroarray
Result Code510116
Result NameDiagnosis
UofM
Result LOINC48000-4
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 511037 Microarray 510117 Interpretation 62365-2
Reflex 1
Order Code511037
Order NameMicroarray
Result Code510117
Result NameInterpretation
UofM
Result LOINC62365-2
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 511037 Microarray 510118 Director Review: 48672-0
Reflex 1
Order Code511037
Order NameMicroarray
Result Code510118
Result NameDirector Review:
UofM
Result LOINC48672-0
Reflex Table for Reflex
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 511037 Microarray 512123 PDF 11502-2
Reflex 1
Order Code511037
Order NameMicroarray
Result Code512123
Result NamePDF
UofM
Result LOINC11502-2