Chromosome Analysis, Tissue Biopsies (Products of Conception, Skin)

CPT: Contact CPT coding department at 800-222-7566, ext 6-8400.
Updated on 06/23/2024
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Synonyms

  • Long-term Culture, Fibroblast Karyotype Study
  • Placental Tissue Chromosome Analysis
  • Spontaneous Abortion Chromosome Analysis
  • Tissue Karyotype

Test Includes

20 Metaphases counted per study; 2 to 3 banded karyotypes per study


Special Instructions

Please include clinical information, previous cytogenetic report or karyotype.

If prior Cell-free DNA/NIPT studies have been performed, include copy of the report.

Call 800-345-4363 if there are any questions. FISH from paraffin blocks can be ordered on fixed specimen with Fluorescence in situ Hybridization (FISH), Paraffin Block [510825].

Please include clinical information, previous cytogenetic report or karyotype.

If prior NIPT studies have been performed, include copy of the report.

Call 800-345-4363 if there any any questions. FISH from paraffin blocks can be ordered on fixed specimen with Fluorescence in situ Hybridization (FISH), Paraffin Block [510825].

Please include clinical information, previous cytogenetic report or karyotype.

If prior Cell-free DNA/NIPT studies have been performed, include copy of the report.

Call 800-345-4363 if there are any questions. FISH from paraffin blocks can be ordered on fixed specimen with Fluorescence in situ Hybridization (FISH), Paraffin Block [510825].


Expected Turnaround Time

11 - 16 days


Related Documents


Specimen Requirements


Specimen

Tissue, skin, products of conception, placental biopsy


Volume

2 to 4 mm³


Container

Submit biopsies in a sterile tube with sterile Ringer's lactate, Hanks' basal salt solution or Labcorp transport medium.

The transport tube (a sterile specimen container with transport medium) is available from Labcorp. Please call customer service at 800-345-4363. Do not use urine containers for shipping.

Saline is not recommended for transport. Do not use urine containers for shipping.

The transport tube (a sterile specimen container with transport medium) is available from Labcorp. Please call customer service at 800-345-4363. Do not use urine containers for shipping.

Submit biopsies in a sterile tube with sterile Ringer's lactate, Hanks' basal salt solution or Labcorp transport medium.

The transport tube (a sterile specimen container with transport medium) is available from Labcorp. Please call customer service at 800-345-4363. Do not use urine containers for shipping.

Saline is not recommended for transport. Do not use urine containers for shipping.


Collection

Aseptically obtain a small piece of tissue with subepidermal layers. Best results are obtained from placental villi, which remain viable much longer than fetal tissue. This is especially true in stillborn cases in which both cord blood and tissue samples are often not viable. If specimen is a product of conception, submit biopsies in a sterile tube with sterile Ringer's lactate, Hanks' basal salt solution or Labcorp transport medium.


Storage Instructions

Refrigerate. Do not freeze.


Causes for Rejection

Gross contamination; necrotic tissue; specimen in fixative


Test Details


Use

This test is used to evaluate possible chromosomal abnormalities as the cause of miscarriage, as well as an extended study of mosaicism found in blood chromosome analysis.


Limitations

Some products of conception may only contain maternal tissue.


Methodology

Tissue culture following enzymatic digestion of tissue. Standard harvesting and G-banding procedures are used with 20 metaphases examined and two karyotypes prepared.


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