Test Details
Methodology
Immunochemiluminometric assay (ICMA)
Result Turnaround Time
1 - 3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
Hepatitis A Virus (HAV) Antibody, Total; Hepatitis B Surface Antibody (anti-HBs); and Hepatitis B c Antibody (anti-HBc), Total
Use
To access patients for immunity to Hepatitis A Virus (HAV) and Hepatitis B Virus (HBV). Detectable total anti-HAV antibody indicates immunity to HAV infection. Although usually not sensitive enough to detect the low level of protective antibody after vaccination, anti-HAV tests also might be positive after hepatitis A vaccination. The detection of anti-HBs antibodies in the absence of anti-HBc antibodies indicates immunity to HBV infection due to vaccination. The detection of both anti-HBs and anti-HBc antibodies indicates immunity due to natural infection.
Special Instructions
This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.
Limitations
The assays in this panel have not been FDA cleared or approved for the screening of blood or plasma donors. Assay performance characteristics have not been established for immunocompromised or immunosuppressed patients, coed blood, or patients less than 2 years of age.
Specimen Requirements
Specimen
Serum or EDTA plasma
Volume
2.5 mL
Minimum Volume
1 mL (Note: This volume does not allow for repeat testing.)
Container
Gel-barrier tube, red-top tube, lavender-top (EDTA) tube, plastic transport tube
Collection Instructions
If tube other than a gel-barrier tube is used, transfer separated serum/plasma to a labelled plastic transport tube. Do not freeze gel-barrier tube (pour off serum first).
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Storage Instructions
Room temperature
Causes for Rejection
Heat-inactivated specimens; cord blood; cadaveric specimens; or body fluids other than serum or EDTA plasma; gross hemolysis; excessive lipemia; improper labeling
References
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 028910 | HAV, HBV Immunity | 006726 | Hep A Ab, Total | 13951-9 | ||
| 028910 | HAV, HBV Immunity | 006718 | Hep B Core Ab, Tot | 13952-7 | ||
| 028910 | HAV, HBV Immunity | 006408 | Hep B Surface Ab, Qual | 22322-2 | ||
| Order Code | 028910 | |||||
| Order Code Name | HAV, HBV Immunity | |||||
| Order Loinc | ||||||
| Result Code | 006726 | |||||
| Result Code Name | Hep A Ab, Total | |||||
| UofM | ||||||
| Result LOINC | 13951-9 | |||||
| Order Code | 028910 | |||||
| Order Code Name | HAV, HBV Immunity | |||||
| Order Loinc | ||||||
| Result Code | 006718 | |||||
| Result Code Name | Hep B Core Ab, Tot | |||||
| UofM | ||||||
| Result LOINC | 13952-7 | |||||
| Order Code | 028910 | |||||
| Order Code Name | HAV, HBV Immunity | |||||
| Order Loinc | ||||||
| Result Code | 006408 | |||||
| Result Code Name | Hep B Surface Ab, Qual | |||||
| UofM | ||||||
| Result LOINC | 22322-2 |
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 126748 | HAVIgM | 006734 | Hep A Ab, IgM | 13950-1 | |
| Reflex 1 | ||||||
| Order Code | 126748 | |||||
| Order Name | HAVIgM | |||||
| Result Code | 006734 | |||||
| Result Name | Hep A Ab, IgM | |||||
| UofM | ||||||
| Result LOINC | 13950-1 | |||||