Integrated 2

Test Number 017170

Test number copied

CPT [MAAA: 81511] or 82105; 82677; 84702; 86336

Synonyms

AFP, Maternal
Down Syndrome

Test Details

Methodology

Chemiluminescent immunoassay

Result Turnaround Time

2 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Integrated 1

Use

Screening test for open neural tube defects, Down syndrome, and trisomy 18

Special Instructions

For test inquiries, call CMBP genetic services at 800-345-4363. Patient must have submitted a previous specimen in the first trimester for the Integrated 1 test. Gestational age will be based on crown rump length provided with the first trimester specimen. Patient information may be provided to the laboratory using the Maternal Prenatal Screening requisition 0900. Testing is provided from 15.0 to 21.9 weeks of gestation.

Limitations

Integrated screening requires two specimens: one collected in the first trimester and one in the second trimester. This test number is for the second trimester portion of the test. This is a screening test. A positive result means that diagnostic testing may be offered to the pregnant woman to determine if a neural tube defect or chromosome abnormality is present.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Serum

Volume

5 mL

Minimum Volume

3 mL

Container

Gel-barrier tube

Collection Instructions

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory.

Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.

Stability Requirements

Temperature	Period
Room temperature	7 days
Refrigerated	14 days
Frozen	14 days
Freeze/thaw cycles	Stable x3

Storage Instructions

Room temperature

Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type

References

Wald NJ, Watt HC, Hackshaw AK. Integrated screening for Down's syndrome based on tests performed during the first and second trimesters. N Engl J Med. 1999 Aug 12; 341(7):461-467.10441601

LOINC® Map

Order Code	Order Code Name	Result Code	Result Code Name	UofM	Result LOINC
017170	Integrated 2	017865	Results		N/A
017170	Integrated 2	017171	Test Results:		49586-1
017170	Integrated 2	017174	FIRST TRIMESTER SAMPLE		N/A
017170	Integrated 2	017175	Crown Rump Length	mm	11957-8
017170	Integrated 2	018058	Crown Rump Length Twin B	mm	11957-8
017170	Integrated 2	017176	CRL Scan		34970-4
017170	Integrated 2	018059	CRL Scan Twin B		34970-4
017170	Integrated 2	018020	Sonographer ID#		49089-6
017170	Integrated 2	017177	Collected On		33882-2
017170	Integrated 2	017212	Gest. Age on Collection Date	weeks	18185-9
017170	Integrated 2	017213	Weight	lbs	29463-7
017170	Integrated 2	017215	SECOND TRIMESTER SAMPLE		N/A
017170	Integrated 2	017216	Collected On		33882-2
017170	Integrated 2	017217	Gestational Age	weeks	18185-9
017170	Integrated 2	017218	Weight	lbs	29463-7
017170	Integrated 2	017254	Maternal Age at EDD	yr	43993-5
017170	Integrated 2	017255	Race		21484-1
017170	Integrated 2	017898	Insulin Dep Diabetes		44877-9
017170	Integrated 2	017256	Number of Fetuses		11878-6
017170	Integrated 2	017257	Nuchal Translucency (NT)	mm	12146-7
017170	Integrated 2	017258	Nuchal Translucency MoM		49035-9
017170	Integrated 2	018057	NT Twin B	mm	12146-7
017170	Integrated 2	018069	NT MoM Twin B		49035-9
017170	Integrated 2	018175	Additional US		N/A
017170	Integrated 2	018224	PAPP-A Value	ng/mL	48407-1
017170	Integrated 2	017260	PAPP-A MoM		76348-2
017170	Integrated 2	017262	AFP Value	ng/mL	1834-1
017170	Integrated 2	017265	AFP MoM		23811-3
017170	Integrated 2	017266	hCG Value	IU/mL	19080-1
017170	Integrated 2	017267	hCG MoM		32166-1
017170	Integrated 2	017268	uE3 Value	ng/mL	2250-9
017170	Integrated 2	017269	uE3 MoM		21264-7
017170	Integrated 2	017280	DIA Value	pg/mL	23883-2
017170	Integrated 2	017281	DIA MoM		36904-1
017170	Integrated 2	018100	Open Spina Bifida		48803-1
017170	Integrated 2	018101	Down Syndrome		43995-0
017170	Integrated 2	018102	Down Syndrome		49090-4
017170	Integrated 2	018103	Trisomy 18		43994-3
017170	Integrated 2	018104	Trisomy 18		47223-3
017170	Integrated 2	017287	OSB Interpretation		49586-1
017170	Integrated 2	017172	Down Syndrome Interpretation		49586-1
017170	Integrated 2	017289	Trisomy 18 Interpretation		49586-1
017170	Integrated 2	017290	Comments:		77202-0
017170	Integrated 2	017856	Note:		N/A
017170	Integrated 2	511933	PDF		11502-2
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017865
Result Code Name	Results
UofM
Result LOINC	N/A
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017171
Result Code Name	Test Results:
UofM
Result LOINC	49586-1
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017174
Result Code Name	FIRST TRIMESTER SAMPLE
UofM
Result LOINC	N/A
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017175
Result Code Name	Crown Rump Length
UofM	mm
Result LOINC	11957-8
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	018058
Result Code Name	Crown Rump Length Twin B
UofM	mm
Result LOINC	11957-8
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017176
Result Code Name	CRL Scan
UofM
Result LOINC	34970-4
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	018059
Result Code Name	CRL Scan Twin B
UofM
Result LOINC	34970-4
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	018020
Result Code Name	Sonographer ID#
UofM
Result LOINC	49089-6
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017177
Result Code Name	Collected On
UofM
Result LOINC	33882-2
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017212
Result Code Name	Gest. Age on Collection Date
UofM	weeks
Result LOINC	18185-9
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017213
Result Code Name	Weight
UofM	lbs
Result LOINC	29463-7
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017215
Result Code Name	SECOND TRIMESTER SAMPLE
UofM
Result LOINC	N/A
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017216
Result Code Name	Collected On
UofM
Result LOINC	33882-2
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017217
Result Code Name	Gestational Age
UofM	weeks
Result LOINC	18185-9
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017218
Result Code Name	Weight
UofM	lbs
Result LOINC	29463-7
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017254
Result Code Name	Maternal Age at EDD
UofM	yr
Result LOINC	43993-5
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017255
Result Code Name	Race
UofM
Result LOINC	21484-1
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017898
Result Code Name	Insulin Dep Diabetes
UofM
Result LOINC	44877-9
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017256
Result Code Name	Number of Fetuses
UofM
Result LOINC	11878-6
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017257
Result Code Name	Nuchal Translucency (NT)
UofM	mm
Result LOINC	12146-7
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017258
Result Code Name	Nuchal Translucency MoM
UofM
Result LOINC	49035-9
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	018057
Result Code Name	NT Twin B
UofM	mm
Result LOINC	12146-7
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	018069
Result Code Name	NT MoM Twin B
UofM
Result LOINC	49035-9
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	018175
Result Code Name	Additional US
UofM
Result LOINC	N/A
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	018224
Result Code Name	PAPP-A Value
UofM	ng/mL
Result LOINC	48407-1
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017260
Result Code Name	PAPP-A MoM
UofM
Result LOINC	76348-2
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017262
Result Code Name	AFP Value
UofM	ng/mL
Result LOINC	1834-1
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017265
Result Code Name	AFP MoM
UofM
Result LOINC	23811-3
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017266
Result Code Name	hCG Value
UofM	IU/mL
Result LOINC	19080-1
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017267
Result Code Name	hCG MoM
UofM
Result LOINC	32166-1
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017268
Result Code Name	uE3 Value
UofM	ng/mL
Result LOINC	2250-9
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017269
Result Code Name	uE3 MoM
UofM
Result LOINC	21264-7
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017280
Result Code Name	DIA Value
UofM	pg/mL
Result LOINC	23883-2
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017281
Result Code Name	DIA MoM
UofM
Result LOINC	36904-1
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	018100
Result Code Name	Open Spina Bifida
UofM
Result LOINC	48803-1
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	018101
Result Code Name	Down Syndrome
UofM
Result LOINC	43995-0
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	018102
Result Code Name	Down Syndrome
UofM
Result LOINC	49090-4
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	018103
Result Code Name	Trisomy 18
UofM
Result LOINC	43994-3
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	018104
Result Code Name	Trisomy 18
UofM
Result LOINC	47223-3
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017287
Result Code Name	OSB Interpretation
UofM
Result LOINC	49586-1
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017172
Result Code Name	Down Syndrome Interpretation
UofM
Result LOINC	49586-1
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017289
Result Code Name	Trisomy 18 Interpretation
UofM
Result LOINC	49586-1
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017290
Result Code Name	Comments:
UofM
Result LOINC	77202-0
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	017856
Result Code Name	Note:
UofM
Result LOINC	N/A
Order Code	017170
Order Code Name	Integrated 2
Order Loinc
Result Code	511933
Result Code Name	PDF
UofM
Result LOINC	11502-2

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