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Complement C1q, Quantitative

CPT

86160

Test Details

Methodology

Radial immunodiffusion (RID)

Result Turnaround Time

7 - 11 days

Use

This test is intended for measuring human C1q in serum.

Special Instructions

State patient's sex on the request form.

Specimen Requirements

References

Calatroni M, Moroni G, Conte E, Stella M, Reggiani F, Ponticelli M. Anti-C1q antibodies: a biomarker for diagnosis and management of lupus nephritis. A narrative review. Front Immunol. 2024 June 13;15:1410032. PubMed 38938561

McMurray JC, Schornack BJ, Weskamp AL, et al. Immunodeficiency: Complement disorders. Allergy Asthma Proc. 2024 Sep 1;45(5):305-309. PubMed 39294906

Son M, Diamond B, Santiago-Schwarz F. Fundamental role of C1q in autoimmunity and inflammation. Immunol Res. 2015 Dec;63(1-3)101-106. PubMed 26410546

Thielens NM, Tedesco F, Bohlson SS, Gaboriaud C, Tenner AJ. C1q: A fresh look upon an old molecule. Mol Immunol. 2017 Sep;89:73-83. PubMed 28601358

van de Bovenkamp FS, Dijkstra DJ, van Kooten C, Gelderman KA, Trouw LA. Circulating C1q levels in health and disease, more than just a biomarker. Mol Immunol. 2021 Dec;140:206-216. PubMed 34735869

 

Custom Additional Information

The complement component 1q (or simply C1q) is a protein complex involved in the complement system, which is part of the innate immune system. C1q together with C1r and C1s form the C1 complex.1

Specimen

Serum

Volume

1 mL

Minimum Volume

0.1 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Storage Instructions

Room temperature

Causes for Rejection

Chylous or lipemic serum; hemolysis; gross bacterial contamination. Plasma should be avoided since fibrin may result in the appearance of nonspecific precipitation, which may adversely affect interpretation.

Collection Instructions

Separate serum from cells.

Stability Requirements

TemperaturePeriod
Room temperature14 days
Refrigerated14 days
Frozen14 days
Freeze/thaw cyclesStable x3

Reference Range

See table.

AgeMale (mg/dL)Female (mg/dL)
0 to 1 yNot establishedNot established
2 to 5 y9.8-18.59.7-19.1
6 to 17 y10.2-19.610.2-19.4
>17 y10.2-20.310.3-20.5

Footnotes

1. Coss SL, Zhou D, Chua GT, et al. The complement system and human autoimmune disease. J Autoimmun. 2023 May;137:102979. PubMed 36535812

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
016824 Complement C1q, Quantitative 4478-4 016824 Complement C1q, Quantitative mg/dL 4478-4
Order Code016824
Order Code NameComplement C1q, Quantitative
Order Loinc4478-4
Result Code016824
Result Code NameComplement C1q, Quantitative
UofMmg/dL
Result LOINC4478-4