Test Details
Methodology
Multiplex flow immunoassay
Result Turnaround Time
1 - 3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
Semiquantitative result of IgG class antibodies
Use
Aids in the diagnosis of Sjögren's syndrome (especially with vasculitis) and lupus patients with Sjögren's overlap syndrome.
Custom Additional Information
SS-A(Ro) is found in 60% to 70% of patients with Sjögren's syndrome and 30% to 40% of patients with SLE. SS-B(La) is found in 50% to 60% of Sjögren's syndrome and 10% to 15% of SLE. SS-A cannot be demonstrated by immunofluorescence (it is soluble in the buffers used), but SS-B may be seen as a speckled antinuclear pattern. SS-A and SS-B are particularly useful in “ANA-negative” cases of SLE, being present in a majority of such cases. Patients who are ANA-positive and who have SS-A but not SS-B are very likely to have nephritis. Antibodies to SS-A are also associated with HLA loci DR3 and DR2 and with hereditary deficiency of C2. Anti-SS-A and anti-SS-B are found in virtually all children with neonatal lupus. Patients with SS-A may also have antibodies to cardiolipin, lupus anticoagulant, and clinical thromboses. This has been termed antiphospholipid antibody syndrome.
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Reference Range
0.0−0.9 AI
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; icterus; lipemia; bacterial contamination
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 012708 | Sjogren's Ab, Anti-SS-A/-SS-B | 012684 | Sjogren's Anti-SS-A | AI | 17792-3 | |
| 012708 | Sjogren's Ab, Anti-SS-A/-SS-B | 012692 | Sjogren's Anti-SS-B | AI | 17791-5 | |
| Order Code | 012708 | |||||
| Order Code Name | Sjogren's Ab, Anti-SS-A/-SS-B | |||||
| Order Loinc | ||||||
| Result Code | 012684 | |||||
| Result Code Name | Sjogren's Anti-SS-A | |||||
| UofM | AI | |||||
| Result LOINC | 17792-3 | |||||
| Order Code | 012708 | |||||
| Order Code Name | Sjogren's Ab, Anti-SS-A/-SS-B | |||||
| Order Loinc | ||||||
| Result Code | 012692 | |||||
| Result Code Name | Sjogren's Anti-SS-B | |||||
| UofM | AI | |||||
| Result LOINC | 17791-5 |