Sjögren's Antibodies (Anti-SS-A/Anti-SS-B)

TEST: 012708
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CPT: 86235(x2)
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Synonyms

  • Anti-La
  • Anti-Ro

Test Includes

Semiquantitative result of IgG class antibodies

Expected Turnaround Time

1 - 3 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Specimen Requirements

Specimen

Serum

Volume

1 mL

Minimum Volume

0.5 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Hemolysis; icterus; lipemia; bacterial contamination

Test Details

Use

Aids in the diagnosis of Sjögren's syndrome (especially with vasculitis) and lupus patients with Sjögren's overlap syndrome.

Methodology

Multiplex flow immunoassay

Reference Interval

0.0−0.9 AI

Additional Information

SS-A(Ro) is found in 60% to 70% of patients with Sjögren's syndrome and 30% to 40% of patients with SLE. SS-B(La) is found in 50% to 60% of Sjögren's syndrome and 10% to 15% of SLE. SS-A cannot be demonstrated by immunofluorescence (it is soluble in the buffers used), but SS-B may be seen as a speckled antinuclear pattern. SS-A and SS-B are particularly useful in “ANA-negative” cases of SLE, being present in a majority of such cases. Patients who are ANA-positive and who have SS-A but not SS-B are very likely to have nephritis. Antibodies to SS-A are also associated with HLA loci DR3 and DR2 and with hereditary deficiency of C2. Anti-SS-A and anti-SS-B are found in virtually all children with neonatal lupus. Patients with SS-A may also have antibodies to cardiolipin, lupus anticoagulant, and clinical thromboses. This has been termed antiphospholipid antibody syndrome.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
012708 Sjogren's Ab, Anti-SS-A/-SS-B 012684 Sjogren's Anti-SS-A AI 17792-3
012708 Sjogren's Ab, Anti-SS-A/-SS-B 012692 Sjogren's Anti-SS-B AI 17791-5

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