Test Details
Methodology
Electrochemiluminescence immunoassay (ECLIA)
Result Turnaround Time
1 - 3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Diagnosis of hyperthyroidism and Graves' disease
Special Instructions
This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.
References
Custom Additional Information
Thyrotropin-receptor antibody is an autoantibody to the thyroid cell receptor for thyroid-stimulating hormone. It can be demonstrated in 90% of patients with Graves' disease, and is the cause of the hyperthyroidism of that condition. The characterization of TRA resolved much confusion about long-acting thyroid stimulator (LATS) and LATS protector, which are both, in fact, thyroid-stimulating autoantibodies which simply behaved differently in animal test systems. These antibodies are present in 50% of euthyroid Graves' disease as well as hyperthyroid patients. They play a major role in the pathogenesis of Graves' disease. Detection of these antibodies is useful in prediction of neonatal hyperthyroidism and prediction of relapse of hyperthyroidism.
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.7 mL (Note: This volume does not allow for repeat testing.)
Container
Gel-barrier tube (preferred) or red-top tube
Collection Instructions
If a red-top tube is used, transfer separated serum to a plastic transport tube.
Stability Requirements
Temperature | Period |
---|---|
Room temperature | Unstable (stability provided by manufacturer or literature reference) |
Refrigerated | 6 days (stability provided by manufacturer or literature reference) |
Frozen | 12 months (stability provided by manufacturer or literature reference) |
Freeze/thaw cycles | Stable x1 (stability provided by manufacturer or literature reference) |
Reference Range
0.0−1.75 units/L
Storage Instructions
Refrigerate.
Causes for Rejection
Citrate plasma specimen; samples collected in heparin or samples from patients on heparin therapy; lipemic or hemolyzed serum samples; improper labeling
LOINC® Map
Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
---|---|---|---|---|---|---|
010314 | Thyrotropin Receptor Ab, Serum | 5385-0 | 010317 | Thyrotropin Receptor Ab, Serum | IU/L | 5385-0 |
Order Code | 010314 | |||||
Order Code Name | Thyrotropin Receptor Ab, Serum | |||||
Order Loinc | 5385-0 | |||||
Result Code | 010317 | |||||
Result Code Name | Thyrotropin Receptor Ab, Serum | |||||
UofM | IU/L | |||||
Result LOINC | 5385-0 |