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Synonyms
- EBV Nuclear Antigen, IgG Antibodies
- EBV-NA, EBNA Antibodies
Expected Turnaround Time
1 - 2 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.2 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x4 |
Causes for Rejection
Hemolysis; lipemia; grossly icteric; visible particulate matter; gross bacterial contamination
Test Details
Use
Aid in the diagnosis of EBV infections (infectious mononucleosis). EBV nuclear antigen (EBNA) IgG antibodies do not appear during the acute phase of infection but appear around 2-4 months after initial clinical presentation and typically persist for life. The presence of EBNA IgG antibodies in healthy individuals typically indicates past immunological exposure to EBV; however, false positive results can occur. Additionally, approximately 5-10% of individuals infected with EBV never develop EBNA IgG antibodies. Because of the complex relationship that exists between the EBV virus/host reaction and clinical manifestation, tracking of EBV antibody patterns may assist in diagnosis of EBV infection. Individual levels of specific antibodies are not necessarily indicative of disease state but can be of diagnostic significance when tracked as an antibody response profile. Antibody response profiles for the different EBV antigens demonstrate a characteristic pattern for silent primary or persistent latent EBV infections, as well as for each of the EBV-associated disease.
Limitations
The results for this test are not by themselves diagnostic and should be considered in association with other clinical data and patient symptoms.
This test is intended for qualitative determination only. The numeric value of the final result above the cutoff is not indicative of the amount of EBNA antibody.
Methodology
Chemiluminescent immunoassay (CLIA)
Reference Interval
• Negative: <18.0 U/mL
• Equivocal: 18.0−21.9 U/mL
• Positive: >21.9 U/mL
Additional Information
Set up and reported Monday thru Friday.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 010272 | EBV Nuclear Antigen Ab, IgG | 30083-0 | 000000 | |||
| 010272 | EBV Nuclear Antigen Ab, IgG | 010276 | EBV Nuclear Antigen Ab, IgG | U/mL | 30083-0 |
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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf