Test Details
Methodology
See individual tests.
Result Turnaround Time
Within 1 day
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
This test is used for initial laboratory assessment of drug, herbal and dietary supplement-induced liver injury.
Limitations
Grossly hemolyzed samples can generate somewhat spurious results. Increased ALT is found with obesity.
Custom Additional Information
According to Fontana et al, the pattern of injury can be categorized as primarily hepatocellular, cholestatic or mixed.
These patterns can be more precisely and quantitatively expressed through the R value at presentation when:
• R value ≥ 5.0 identifies hepatocellular liver injury
• R value 2.1- 4.9 identifies mixed liver injury
• R value ≤ 2.0 identifies cholestatic liver injury
When liver injury falls into hepatocellular or mixed categories, it may be important to exclude other causes of liver injury.1
Specimen Requirements
Specimen
Serum (preferred) or plasma
Volume
1 mL
Minimum Volume
0.7 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube, gel-barrier tube or green-top (lithium heparin) tube; do not use oxalate, EDTA or citrate plasma
Collection Instructions
Separate serum or plasma from cells within 45 minutes of collection.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 7 days |
Refrigerated | 14 days |
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Gross hemolysis; excessive lipemia; improper labeling
Footnotes
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 010035 | Drug Induced Liver w R Value | 001107 | Alkaline Phosphatase | IU/L | 6768-6 | |
| 010035 | Drug Induced Liver w R Value | 001545 | ALT (SGPT) | IU/L | 1742-6 | |
| 010035 | Drug Induced Liver w R Value | 010036 | DILI R Value | N/A | ||
| Order Code | 010035 | |||||
| Order Code Name | Drug Induced Liver w R Value | |||||
| Order Loinc | ||||||
| Result Code | 001107 | |||||
| Result Code Name | Alkaline Phosphatase | |||||
| UofM | IU/L | |||||
| Result LOINC | 6768-6 | |||||
| Order Code | 010035 | |||||
| Order Code Name | Drug Induced Liver w R Value | |||||
| Order Loinc | ||||||
| Result Code | 001545 | |||||
| Result Code Name | ALT (SGPT) | |||||
| UofM | IU/L | |||||
| Result LOINC | 1742-6 | |||||
| Order Code | 010035 | |||||
| Order Code Name | Drug Induced Liver w R Value | |||||
| Order Loinc | ||||||
| Result Code | 010036 | |||||
| Result Code Name | DILI R Value | |||||
| UofM | ||||||
| Result LOINC | N/A |