Test Details
Methodology
Polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (SSOP)
This is a class I allele-specific test.
Result Turnaround Time
3 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Determine the presence of B57 antigen
Special Instructions
If you have questions, please telephone 800-533-1037 (HLA customer service) for assistance in selecting the proper HLA test for the patient.
Limitations
Even with appropriate precautions, an occasional specimen may not be satisfactory for testing. In such cases, an additional specimen should be collected for testing.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Custom Additional Information
Abacavir hypersensitivity has been shown to be associated with the human leukocyte antigen (HLA) B*57:01 of the major histocompatibility complex (MHC). The MHC family of genes codes for a highly variable set of cell surface glycoproteins (HLAs) that play a critical role in presenting antigens to T cell receptors to elicit an immune response. The presence of the HLA-B*57:01 allele increases the susceptibility to abacavir hypersensitivity in several populations studied.
Specimen Requirements
Specimen
Whole blood or buccal swabs
Volume
7 mL whole blood or four buccal swabs
Minimum Volume
3 mL whole blood or four buccal swabs
Container
Lavender-top (EDTA) tube or four buccal swabs in a sealed envelope (buccal swab kit). When submitting buccal swabs, please use a buccal swab kit provided by LabCorp. To obtain the buccal swab kit, please telephone 800-533-1037.
Storage Instructions
Maintain blood specimen at room temperature. Keep buccal swabs dry and at room temperature.
Causes for Rejection
Hemolysis; clotted specimen; insufficient amount of DNA on buccal swabs
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 006926 | HLA B5701 Test | 42358-2 | 006930 | Result | 42358-2 | |
| Order Code | 006926 | |||||
| Order Code Name | HLA B5701 Test | |||||
| Order Loinc | 42358-2 | |||||
| Result Code | 006930 | |||||
| Result Code Name | Result | |||||
| UofM | ||||||
| Result LOINC | 42358-2 |