Hepatitis A Virus (HAV) Antibody, Total

CPT: 86708
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Synonyms

  • anti-HAV
  • Antibody to Hepatitis A Virus
  • HAV

Special Instructions

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.


Expected Turnaround Time

1 - 2 days


Related Documents


Specimen Requirements


Specimen

Serum or plasma


Volume

1 mL


Minimum Volume

0.4 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube, gel-barrier tube or lavender-top (EDTA) tube


Collection

If tube other than a gel-barrier tube is used, transfer separated serum or plasma to a plastic transport tube. Do not freeze gel-barrier tube (pour off serum first).


Storage Instructions

Room temperature


Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3


Causes for Rejection

Non-EDTA plasma specimen; PST gel-barrier tube; grossly hemolyzed specimens


Test Details


Use

This assay is used to detect total antibodies (IgG and IgM) against Hepatitis A virus (HAV) and may be helpful when assessing HAV immunity. The detection of total antibodies cannot differentiate between vaccination, previously resolved infection, or active infection. If active hepatitis A infection is suspected, HAV IgM testing should be performed. Hepatitis A is a vaccine-preventable disease of the liver caused by the Hepatitis A virus (HAV). HAV is transmitted via the fecal-oral route, usually from direct person-to-person contact or consumption of contaminated food or water. Hepatitis A is an acute, self-limited disease that does not result in chronic infection. HAV IgG antibodies produced in response to vaccination and/or HAV infection persist for life and protect against reinfection.


Limitations

This assay has not been FDA cleared or approved for the screening of blood or plasma donors. Assay performance characteristics have not been established for immunocompromised or immunosuppressed individuals. This assay does not differentiate IgG and IgM.


Methodology

Immunochemiluminometric assay (ICMA)


Reference Interval

Negative


Additional Information

See table.

HAV antibody testing interpretation chart

HAV Total Antibody

HAV IgM

Comments

Negative

Not done

No evidence of vaccination or previous infection;

Susceptible to Hepatitis A infection

Positive

Not done

Consistent with recent or remote Hepatitis A infection or antibody response to HAV vaccination

Positive

Negative

Consistent with resolved Hepatitis A infection or antibody response to HAV vaccination

Positive

Positive

Consistent with active Hepatitis A infection


References

Miller JM, Binnicker MJ, Campbell S, et al. A guide to utilization of the microbiology laboratory for diagnisis of infectios diseases: 2018 update by the Infectious Disease Society of America and the American Society for Microbiology. Clin Infect Dis. 2018 Aug 31;67(6):813-816.30169655
Nelson NP, Wenk MK, Hofmeister MG, et al. Prevention of hepatitis A virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices, 2020. MMWR Recomm Rep. 2020 Jul 3;69(5):1-38.32614811

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
006726 Hep A Ab, Total 13951-9 006726 Hep A Ab, Total 13951-9

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