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For hours, walk-ins and appointments.Synonyms
- AMA
Expected Turnaround Time
2 - 3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination; heat-treated specimen; specimen with preservative added
Test Details
Use
The presence of mitochondrial antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of primary biliary cirrhosis (PBC).
Limitations
The presence of immune complexes in the patient's sample may cause an increased level of nonspecific binding and produce false-positive results. Not all PBC patients are positive for mitochondrial antibodies. Results of this assay should be used in conjunction with clinical findings and other serologic tests.
Methodology
Enzyme-linked immunosorbent assay (ELISA)
Reference Interval
• Negative: 0.0−20.0
• Equivocal: 20.1−24.9
• Positive: >24.9
Additional Information
Antimitochondrial antibodies (AMA) have been reported in 90% to 96% of patients with primary biliary cirrhosis. AMA are also occasionally found in sera of patients with other liver diseases, including chronic active hepatitis, cryptogenic cirrhosis, as well as in patients with clinical but no biochemical evidence of liver disease. The M2 antigen used is strongly associated with PBC, while other types (M1, M2, M5, and M6) are associated with a wide variety of conditions.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 006650 | Mitochondrial (M2) Antibody | 14251-3 | 006652 | Mitochondrial (M2) Antibody | Units | 14251-3 |
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