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For hours, walk-ins and appointments.Mononucleosis Test, Qualitative With Reflex to Titer on Positives
CPT:
86308
Synonyms
- Heterophil Agglutinins
- Heterophil Antibodies
- Infectious Mononucleosis (IM) Antibodies
Test Includes
Endpoint titer is performed at an additional charge when preliminary qualitative test is positive.
Expected Turnaround Time
1 - 2 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Storage Instructions
Maintain specimen at room temperature.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination
Test Details
Use
Detect heterophil antibodies related to infectious mononucleosis
Limitations
Rare patients may have positive heterophil agglutinins after a negative initial test. Ten percent of cases of true EBV mononucleosis may have negative heterophil agglutinins. These may be diagnosed with EBV specific tests.
Methodology
Latex agglutination (LA)
Reference Interval
Negative
Additional Information
A positive test in the presence of consistent clinical and/or hematologic findings confirms the diagnosis of infectious mononucleosis. Approximately 10% of mononucleosis syndromes are heterophil-negative. In some of these, antibody to specific Epstein-Barr viral antigen can be demonstrated. Others may be due to CMV, HSV, or toxoplasmosis. Although this classic test has excellent specificity, false-positive tests can occur and may lead to diagnostic confusion.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 006536 | Mono Qual W/Rflx Qn | 5213-4 | 006536 | Mono Qual W/Rflx Qn | 5213-4 |
| Reflex Table for Mono Qual W/Rflx Qn | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 006569 | Mononucleosis Test, Quant | 016569 | Mono Titer | 6424-6 | |
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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf