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For hours, walk-ins and appointments.Test Includes
Titer of the patient's serum against type O blood cells at 2°C to 8°C
Special Instructions
This test is not specific for Mycoplasma pneumoniae. For diagnosis of Mycoplasma pneumoniae infections, see Mycoplasma pneumoniae Antibodies, IgG, IgM [163758].
Expected Turnaround Time
2 - 3 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Collection
Transport blood immediately to laboratory. Incubate at 37°C and allow to clot at 37°C. Separate serum from cells. If there is not a 37°C incubator, allow to clot at room temperature and separate serum from cells immediately after clotting.
Storage Instructions
Do not refrigerate prior to separation of serum from red cells. Store separated serum in refrigerator.
Causes for Rejection
Refrigeration of the specimen before separating serum from cells
Test Details
Use
Detection of the presence of cold agglutinins in patients with suspected cold agglutinin disease
Limitations
False-negative results may occur if the sample is refrigerated prior to the separation of the serum from the red blood cells. This test is not a direct measure of the clinical significance of the cold agglutinin and must be used in conjunction with the patient’s clinical presentation and other laboratory values. Normal individuals may have low levels of cold agglutinins that have no clinical significance.
Methodology
Hemagglutination
Reference Interval
Negative: <1:32
References
Fung MK, Grossman JB, Hillyer CD, Westoff CM, eds. AABB Technical Manual. 18th ed. Bethesda, Md: American Association of Blood Banks;2014.
Petz LD, Garratty G. Immune Hemolytic Anemias. 2nd ed. New York: Churchill Livingstone/Elsevier Science;2004.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 006353 | Cold Agglutinin Titer, Quant | 5098-9 | 006353 | Cold Agglutinin Titer, Quant | 5098-9 |
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